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tag biochemistry inflammation disease medicine insulin

Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Your Body Is Teeming with Weed Receptors
Megan Scudellari | Jul 16, 2017 | 10+ min read
And the same endocannabinoid system that translates marijuana's buzz-inducing compounds into a high plays crucial roles in health and disease outside the brain.
How Gaining and Losing Weight Affects the Body
Abby Olena, PhD | Jan 17, 2018 | 3 min read
Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and gut microbiota that accompany shifts in body mass.
diabetes complications type 2 biomarker blood test screen hydroxymethylation epigenetics cytosine
Blood-Based Epigenetic Screen Tests for Diabetes Complications
Katarina Zimmer | Oct 1, 2019 | 4 min read
Researchers could accurately detect life-threatening vascular complications in type 2 diabetes patients by analyzing hydroxymethylated cytosines in freely circulating DNA.
The Skinny on Fat Cells
Anna Azvolinsky | Nov 1, 2015 | 8 min read
Bruce Spiegelman has spent his career at the forefront of adipocyte differentiation and metabolism.
Inspired by Nature
Daniel Cossins | Aug 1, 2015 | 10+ min read
Researchers are borrowing designs from the natural world to advance biomedicine.
Longevity
Jill Adams(juadams@the-scientist.com) | May 8, 2005 | 7 min read
During autophagy-literally "self-eating"-cells deliver cytoplasmic constituents, including whole organelles, to the lysosome for degradation.
X-ray Vision in Structural Genomics
Gregory Smutzer | Jun 10, 2001 | 10 min read
Updated! Suppliers of Tools for X-ray Crystallography Courtesy of Amersham Pharmacia BiotechDetail of the electron density map of deacetoxycephalosporin C synthase from Streptomyces clavuligerus. Two important approaches can be used to determine the three-dimensional structure of macromolecules. Nuclear magnetic resonance (NMR) spectroscopy yields information on the structure of proteins in solution, but it has a size limitation of approximately 150 amino acid residues (about 16,500 daltons),
Assays by the Score
Deborah Fitzgerald | May 27, 2001 | 9 min read
Click to view the PDF file: Bead-based Fluorescent Multiplex Protein Analysis Systems Courtesy of LINCO ResearchLabMAP-based systems use internally dyed fluorescent microspheres to analyze as many as 100 different analytes concurrently. Today's competitive, high-paced research environment has stimulated the development of a host of approaches for rapid, cost-efficient analyses of large numbers of samples. In keeping with this trend, methods for simultaneously analyzing multiple species in a g
A Weighty Matter: Neuropeptides Involved In Appetite And Energy Homeostasis
Deborah Wilkinson | Sep 12, 1999 | 10+ min read
Date: September 13, 1999Table of Neurochemical Manufacturers The hypothalamus has long been known as a control center for feeding and weight control behaviors. Complex regulatory feedback loops enable this portion of the brain to determine satiety and metabolic activity. Not surprisingly, the control mechanisms are complex and involve different biochemical pathways.1,2,3 Image courtesy of Jeffrey M. Friedman An ob/ob mouse stacking up against its lean counterparts A series of pioneering expe

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