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» biochemistry and genetics & genomics

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image: Sense and Sensibility

Sense and Sensibility

By | May 1, 2016

Tailored combinations of a reporter and a ligand-binding domain allow for sensing just about any molecule of interest.

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image: RNA Methylation Dynamics

RNA Methylation Dynamics

By , and | January 1, 2016

Additions to the bases of RNA molecules can be written, read, and erased.

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image: Going Viral

Going Viral

By | September 1, 2013

Bacteriophages shuttle genes between diverse ecosystems.

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image: Cellular Engineering in Context

Cellular Engineering in Context

By , and | August 1, 2013

Designing circuits in living cells is messy business.

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image: The Epigenetic Lnc

The Epigenetic Lnc

By | October 1, 2012

Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For exa

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image: Ubiquitin Chains in Action

Ubiquitin Chains in Action

By | July 1, 2012

Present in every tissue of the body, ubiquitin appears to be involved in a dizzying array of functions, from cell cycle and division to organelle and ribosome biogenesis, as well as the response to viral infection. The protein plays at least two role

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image: Ubiquitin basics

Ubiquitin basics

By | July 1, 2012

Despite its discovery as a protein that seems to show up everywhere, at least in eukaryotic cells, researchers are only beginning to scratch the surface of all of the cellular functions involving ubiquitin. 

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image: Designing Transition-State Inhibitors

Designing Transition-State Inhibitors

By | May 1, 2012

A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. 

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image: Death or Damage of Dopamine Neurons

Death or Damage of Dopamine Neurons

By | February 1, 2011

The hallmark pathology of Parkinson’s disease is the damage and death of dopamine producing neurons in the brain. 

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