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image: The Science of Acupuncture

The Science of Acupuncture

By | May 1, 2013

Research is uncovering connective tissue's role in the benefits of the ancient practice.

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image: All In Proportion

All In Proportion

By | March 2, 2013

Drosophila insulin-like peptides (dILPs) regulate part of the signaling pathway that helps keep organs growing in proportion during development.

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image: Ubiquitin Chains in Action

Ubiquitin Chains in Action

By | July 1, 2012

Present in every tissue of the body, ubiquitin appears to be involved in a dizzying array of functions, from cell cycle and division to organelle and ribosome biogenesis, as well as the response to viral infection. The protein plays at least two role

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image: Ubiquitin basics

Ubiquitin basics

By | July 1, 2012

Despite its discovery as a protein that seems to show up everywhere, at least in eukaryotic cells, researchers are only beginning to scratch the surface of all of the cellular functions involving ubiquitin. As a monomer, ubiquitin can bind and tag ot

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image: Digging the Underground Life

Digging the Underground Life

By | June 1, 2012

A rare peek inside the subterranean home of the naked mole-rat

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image: Designing Transition-State Inhibitors

Designing Transition-State Inhibitors

By | May 1, 2012

A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. In order to replicate the structure of an enzyme’s transition state, whic

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image: Calcium and the Pancreas

Calcium and the Pancreas

By | February 1, 2012

Normal pancreatic function depends on the precise flow of calcium within and into the acinar cells of the organ. When food is eaten, low concentrations of the pancreas-stimulating hormone cholecystokinin or of the neurotransmitter acetylcholine cause

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image: Lost in Space

Lost in Space

By | September 1, 2011

Looking for a more realistic way to study memory, we turned to place cells­­—­a network of cells that record a rat’s memory of an environment. Each place cell would fire only when the rat was in one particular location in space, creating a map as the

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image: Molecular Learning

Molecular Learning

By | September 1, 2011

Long-term potentiation (LTP), discovered in the 1970s, was later shown to be the molecular basis of memory. Since many diseases of aging affect memory, could memory formation and storage be altered by the same mechanisms in normal aging and diseased

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image: The Seat of Memory

The Seat of Memory

By | September 1, 2011

Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to t

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