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» neurodegeneration and physiology

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image: Mind the Clock

Mind the Clock

By | September 1, 2013

Many of the body's tissues can tell time, and these peripheral clocks can be influenced by environmental cues, such as the timing of food consumption.

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image: The Science of Acupuncture

The Science of Acupuncture

By | May 1, 2013

Research is uncovering connective tissue's role in the benefits of the ancient practice.

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image: All In Proportion

All In Proportion

By | March 2, 2013

Drosophila insulin-like peptides (dILPs) regulate part of the signaling pathway that helps keep organs growing in proportion during development.

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image: Digging the Underground Life

Digging the Underground Life

By | June 1, 2012

A rare peek inside the subterranean home of the naked mole-rat

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image: Calcium and the Pancreas

Calcium and the Pancreas

By | February 1, 2012

Normal pancreatic function depends on the precise flow of calcium within and into the acinar cells of the organ. 

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image: Lost in Space

Lost in Space

By | September 1, 2011

Looking for a more realistic way to study memory, we turned to place cells­­—­a network of cells that record a rat’s memory of an environment. 

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image: Molecular Learning

Molecular Learning

By | September 1, 2011

Long-term potentiation (LTP), discovered in the 1970s, was later shown to be the molecular basis of memory. 

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image: The Seat of Memory

The Seat of Memory

By | September 1, 2011

Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to the aging process.

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image: The Cytokine Cycle

The Cytokine Cycle

By | September 1, 2011

The initiating cause of Alzheimer’s disease is still unknown. However, from our studies it’s clear that many types of neuronal damage—­­from traumatic brain injury, to epilepsy, infection, or genetic predisposition—­can activate brain immune cells—microglia and astrocytes-- promoting them to produce IL-1 and S100 inflammatory cytokines.

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image: Stress and Inflammation

Stress and Inflammation

By | February 1, 2011

Stress and inflammation Cardiovascular disease, including coronary artery disease and stroke, is the single greatest cause of death worldwide and is a major burden on health services and society. 

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