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Cancer May Be Driven by DNA Outside of Chromosomes
Paul Mischel | Apr 1, 2021 | 10+ min read
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Contributors
Asher Jones and Kerry Grens | Apr 1, 2021 | 3 min read
Meet some of the people featured in the April 2021 issue of The Scientist.
“Rogue” Protein Could Contribute to Humans’ High Cancer Rates
Asher Jones | Apr 1, 2021 | 2 min read
A mutant protein called Siglec-XII may promote carcinoma progression in humans, but inactivation of its gene seems to avoid the problem, according to a study.
Infographic: Steps in Cancer Metastasis
Shawna Williams | Apr 1, 2021 | 2 min read
It’s now thought that in many cases, cancer cells disseminate from the primary tumor site early on and lie dormant for long periods rather than only venturing out from primary tumors at an advanced stage.
A Bright New Tool to Record Cellular Interactions
Lisa Winter | Apr 1, 2021 | 3 min read
The G-baToN prototype transfers GFP between cells, illuminating cell-cell contacts.
New Understanding of Metastasis Could Lead to Better Treatments
Shawna Williams | Apr 1, 2021 | 10+ min read
Recent insights, such as the recognition that disseminated cancer cells can lie dormant for years before seeding secondary tumors, suggest novel strategies for fighting metastatic disease.
Bisrat Debeb Models How Cancer Spreads to the Brain
Catherine Offord | Apr 1, 2021 | 3 min read
From his student days in veterinary medicine in Ethiopia to running a lab on metastasis at MD Anderson Cancer Center, Debeb has a passion for understanding how living things work.
Infographic: The Role of Extrachromosomal DNA in Cancer
Paul Mischel | Apr 1, 2021 | 2 min read
Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.
Gloria Echeverria Investigates an Insidious Form of Breast Cancer
Max Kozlov | Dec 1, 2020 | 3 min read
The newly minted Baylor College of Medicine faculty member is working to crack the mystery of triple negative breast cancer.
Cheese Preservative Slows Oral Cancer Spread in Mice: Study
Max Kozlov | Oct 1, 2020 | 4 min read
The results add to mounting evidence of microbes’ roles in tumor growth and point to the possibility of impeding malignancies by inhibiting bacteria.
A Trick that Helps Horses and Cattle Avoid Metastatic Cancer
Shawna Williams | Apr 1, 2020 | 2 min read
Researchers find connective tissue has a crucial role to play in whether cancer cells metastasize.
Colon Cancer Uses a Regenerative Playbook to Metastasize
Shawna Williams | Apr 1, 2020 | 5 min read
A study finds similarities between cells that heal wounds and those that lead deadly cancerous invasions.
Hadiyah-Nicole Green Targets Cancer With Lasers
Emily Makowski | Apr 1, 2020 | 3 min read
Spurred by family tragedy, the medical physicist wants to treat cancer in a new way.
Cracking Down on Cancer: A Profile of Owen Witte
Diana Kwon | Apr 1, 2020 | 9 min read
Through his studies on cancer-causing viruses, the University of California, Los Angeles, professor has helped develop lifesaving treatments.
Zika as Cancer Buster?
Amy Schleunes | Apr 1, 2020 | 2 min read
By infecting glioblastoma cells but not healthy brain tissue, some form of the virus could serve a therapeutic purpose.
Natural Killer Cell Therapies Catch Up to CAR T
Bianca Nogrady | Apr 1, 2020 | 8 min read
There’s a new cell-based cancer immunotherapy on the block.
CAR T Cell Adds Scorpion Venom to Tackle Tumor Heterogeneity
Amy Schleunes | Mar 24, 2020 | 5 min read
A newly engineered CAR T cell that incorporates a peptide isolated from the venom of the deathstalker scorpion has broad brain tumor–binding capabilities that will be investigated in an upcoming clinical trial.
Infographic: How Some X-Chromosome Genes Escape Inactivation
Amber Dance | Mar 1, 2020 | 2 min read
About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time.
Genes that Escape Silencing on the Second X Chromosome May Drive Disease
Amber Dance | Mar 1, 2020 | 10+ min read
When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.
Image of the Day: Synthetic Scaffolds
Amy Schleunes | Feb 27, 2020 | 1 min read
Three-dimensional polymer matrices offer researchers a new representation of the extracellular matrix that can be used to study the growth of cancer cells.
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