Gene therapies typically involve the introduction of genetic material into target cells to replace or supplement an existing, usually dysfunctional, gene. Techniques for delivering the corrective payload vary widely. Many gene therapies utilize modif
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Telomeres are repetitive, noncoding sequences that cap the ends of linear chromosomes. They consist of hexameric nucleotide sequences (TTAGGG in humans) repeated hundreds to thousands of times. Telomeres protect the protein-coding sequences of DNA on
A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. In order to replicate the structure of an enzyme’s transition state, whic
A lot changes in a child’s body over the course of development, and not all changes occur linearly: gene expression can fluctuate, and organs can perform different functions on the way to their final purpose in the body. Here are some of the key deve
The Pediatric Research Equity Act (PREA) of 2003 requires that companies developing new drugs that could be used to treat a condition in children perform clinical trials in kids before winning FDA approval. The Best Pharmaceuticals for Children Act (
Vitamin D has a variety of actions in the body. It binds to the vitamin D receptor (VDR), which then binds to the retinoid X receptor (RXR) and activates the expression of numerous genes. Through this mechanism, vitamin D promotes calcium absorption
Normal pancreatic function depends on the precise flow of calcium within and into the acinar cells of the organ. When food is eaten, low concentrations of the pancreas-stimulating hormone cholecystokinin or of the neurotransmitter acetylcholine cause
In fewer than 15 years, nanomedicine has gone from fantasy to reality.
Recent clinical trials have reignited the interest in simple anti-inflammatory drugs like aspirin for controlling the inflammation associated with cancer. The results suggest that these drugs reduced the risk of relapse as well as cancer formation ac
Stress and inflammation Cardiovascular disease, including coronary artery disease and stroke, is the single greatest cause of death worldwide and is a major burden on health services and society. Most resources are currently directed towards surg
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