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drug development

Apr 1, 2024 | 3 min read

MEGA CRISPR: Engineering Better Immunotherapies with RNA Editing

Multi-targeted Cas13 screens help researchers avoid permanent DNA cuts and evade T cell exhaustion.
3D rendered RNA strand
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Apr 1, 2024 | 2 min read

Enter Our 2024 Top 10 Innovations Contest

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A scientist in the middle of the screen is in a lab coat in a laboratory on the left but is dressed in a suit giving a scientific presentation in a board room on the right.
Starting Up a New Endeavor
Shelby Bradford, PhD | Apr 1, 2024 | 2 min read
In his lab, Hashim Al-Hashimi investigated how RNA molecules move. Along the way, he founded a company.
An illustration of purple-colored single domain antibodies floating in front of a black background.
Single Domain Antibodies: Small but Mighty Therapeutics
The Scientist | Mar 22, 2024 | 1 min read
Discover the benefits of VHH antibody-based therapies.
<strong >How Cloud Labs and Remote Research Shape Science&nbsp;</strong>
How Cloud Labs and Remote Research Shape Science 
Priyom Bose, PhD | 6 min read
Remote research via cloud labs makes it possible for scientists to conduct complex experiments from a distance.
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Infographic: Vaccinating Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 1 min read
Cancer vaccines offer the opportunity to use the patient’s own immune system in the fight against tumors.
A blue background with colorful illustrated viral particles
Delivering Prime Editors With Virus-like Particles
Deanna MacNeil, PhD | Mar 11, 2024 | 3 min read
An iterative engineering approach to improve prime editor delivery helped scientists correct genetic vision defects in mice.
A microplate with pink or blue solution in different wells.
High Throughput Screening Models Ramp up Lead Discovery
The Scientist | 1 min read
Fast, automated, and relevant biological tools and technologies help researchers hunt for more hits.
Making Moves Toward Cell Therapy for Diabetes
Deanna MacNeil, PhD | Feb 20, 2024 | 3 min read
A step-by-step cell culture process may improve the quantity and quality of cell replacement therapies.
Orange powder in a silver spoon, surrounded by orange pills on a blue background.
Turmeric Tackles Antimicrobial Resistance
Danielle Gerhard, PhD | Jan 1, 2024 | 2 min read
An active ingredient in turmeric interacts with light to resensitize pathogens to antibiotics.
From the Expert: Click Chemistry and Bioorthogonal Applications
From the Expert: Click Chemistry and Bioorthogonal Applications
The Scientist | 1 min read
Carolyn Bertozzi discusses her recent work on targeted degradation therapies that rely on bioorthogonal chemistry.
Abstract illustration depicting coronavirus research concept.
Curiosity and Compassion Fuel Rare Disease Research
The Scientist Staff | Jan 1, 2024 | 1 min read
Lauren Drouin shares how personal connections and scientific curiosities drive her work on gene therapy viral vectors. 
Infographic showing how a viral protein expression method links proteins and their coding instructions
Infographic: Phage Display Allows Rapid Screening of Millions of Peptides
Shelby Bradford, PhD | Dec 4, 2023 | 3 min read
A viral protein expression method links proteins and their coding instructions, enabling easier target identification for downstream analysis.
A close up of several modular puzzle pieces.
Making Connections: Click Chemistry and Bioorthogonal Chemistry
Deanna MacNeil, PhD | 5 min read
Simple, quick, and modular reactions allow researchers to create useful molecular structures from a wide range of substrates.
A Y-shaped pink, blue, and light green antibody is in focus on a background of blurred pink and purple color, with other antibodies out of focus in the background.
Phage Display: Finding the One in a Million
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
A combinatorial approach enabled high-throughput screening of protein libraries for desired target binding.
Engineered RNA Export From Living Cells
Danielle Gerhard, PhD | Dec 1, 2023 | 1 min read
A nondestructive approach for packaging, exporting, and delivering RNA provides a glimpse into the dynamic lives of cells.
Mitigating Biopharmaceutical Impurities in Monoclonal Antibody Therapeutic Manufacturing
Host Cell Protein and Impurity Risk Mitigation in Monoclonal Antibody Therapeutic Manufacturing
The Scientist Staff | 1 min read
In this webinar, Andrew Hamilton and Joe Hirano will explore how to detect and remove host cell proteins and other impurities during biologics manufacturing.
A scientist not in frame is holding a plant leave with forceps in one hand and a petri dish with more leaves in the other.
Mean, Green, Antibody-producing Machines
Shelby Bradford, PhD | Dec 1, 2023 | 2 min read
A plant-based monoclonal antibody goes head-to-head with its commercial counterpart to target tumors in mice.
Conceptual image of scientific advancement depicting a large spherical object and wire frame image of a running human.
Organoids: The New Frontier
The Scientist | Nov 22, 2023 | 1 min read
Explore the latest in organoid production for studying development, disease, and drug screening.
A microscopy image of intestinal crypts in human tissue.
Trust Your Gut: Screening Drugs Using Novel Intestinal Models
The Scientist and Altis Biosystems | 4 min read
Discover how cutting-edge nonclinical in vitro models better recapitulate the human gastrointestinal tract.
Light blue dots forming keys over a navy background with small red dots.
A Double Lock Gates Calcium Signaling
Danielle Gerhard, PhD | Nov 13, 2023 | 6 min read
Recent studies settle a debate over how the second messenger NAADP, with no known binding site, evokes calcium release from ion channels. 
Green leaves in a row with varied degrees of black spots on a black background.
A New Drug Fixes a Leak Caused by Bacteria
Kamal Nahas, PhD | Nov 8, 2023 | 5 min read
Researchers discovered how virulent bacterial proteins leech nutrients from plant cells, leading to a potential treatment for diseased crops.
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