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image: Ubiquitin Chains in Action

Ubiquitin Chains in Action

By | July 1, 2012

Present in every tissue of the body, ubiquitin appears to be involved in a dizzying array of functions, from cell cycle and division to organelle and ribosome biogenesis, as well as the response to viral infection. The protein plays at least two role


image: Ubiquitin basics

Ubiquitin basics

By | July 1, 2012

Despite its discovery as a protein that seems to show up everywhere, at least in eukaryotic cells, researchers are only beginning to scratch the surface of all of the cellular functions involving ubiquitin. 


image: Telomere Basics

Telomere Basics

By | May 1, 2012

Telomeres are repetitive, noncoding sequences that cap the ends of linear chromosomes. They consist of hexameric nucleotide sequences (TTAGGG in humans) repeated hundreds to thousands of times. 


image: How Autophagy Works

How Autophagy Works

By | February 1, 2012

There are five steps of autophagosome biogenesis: induction, expansion, vesicle completion, fusion, and cargo degradation. 


image: Taste in the Mouth, Gut, and Airways

Taste in the Mouth, Gut, and Airways

By | December 1, 2011

The tongue may be the epicenter of taste sensation, but taste receptors are scattered throughout the digestive and respiratory tracts.


image: Helpful Bacterial Metabolites

Helpful Bacterial Metabolites

By | August 1, 2011

While gut microbiota appear to have both positive and negative impacts on our  health, in the guts of healthy, lean individuals, the good outweighs the bad.  


image: Harmful Bacterial Metabolites

Harmful Bacterial Metabolites

By | August 1, 2011

Gut bacteria that feed on healthy food appear to amplify the nutritional benefits of those foods. However, they also appear to amplify the undesirable effects of unhealthy food. 


image: Exosome Basics

Exosome Basics

By | July 1, 2011

Exosomes are small membrane vesicles secreted by most cell types. Internal vesicles form by the inward budding of cellular compartments known as multivesicular endosomes (MVE). 


image: Where Cancer and Inflammation Intersect

Where Cancer and Inflammation Intersect

By | April 1, 2011

Recent clinical trials have reignited the interest in simple anti-inflammatory drugs like aspirin for controlling the inflammation associated with cancer. 


image: Epigenetics—A Primer

Epigenetics—A Primer

By | March 1, 2011

Epigenetic events regulate the activities of genes without changing the DNA sequence. Different genes are expressed depending on the methyl-marks attached to DNA itself and by changes in the structure and/or composition of chromatin. 


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