Long-term potentiation (LTP), discovered in the 1970s, was later shown to be the molecular basis of memory. Since many diseases of aging affect memory, could memory formation and storage be altered by the same mechanisms in normal aging and diseased
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Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to t
The initiating cause of Alzheimer’s disease is still unknown. However, from our studies it’s clear that many types of neuronal damage—from traumatic brain injury, to epilepsy, infection, or genetic predisposition—can activate brain immune cells—
While gut microbiota appear to have both positive and negative impacts on our health, in the guts of healthy, lean individuals, the good outweighs the bad. Gut bacteria, most of which reside in the large intestine, process many otherwise indigest
Gut bacteria that feed on healthy food appear to amplify the nutritional benefits of those foods. However, they also appear to amplify the undesirable effects of unhealthy food. Here are a few examples. Read the full story.
Exosomes are small membrane vesicles secreted by most cell types. Internal vesicles form by the inward budding of cellular compartments known as multivesicular endosomes (MVE). When MVE fuse with the plasma membrane, these internal vesicles are relea
Recent clinical trials have reignited the interest in simple anti-inflammatory drugs like aspirin for controlling the inflammation associated with cancer. The results suggest that these drugs reduced the risk of relapse as well as cancer formation ac
Epigenetic events regulate the activities of genes without changing the DNA sequence. Different genes are expressed depending on the methyl-marks attached to DNA itself and by changes in the structure and/or composition of chromatin. The main compone
Stress and inflammation Cardiovascular disease, including coronary artery disease and stroke, is the single greatest cause of death worldwide and is a major burden on health services and society. Most resources are currently directed towards surg
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