A mutant protein called Siglec-XII may promote carcinoma progression in humans, but inactivation of its gene seems to avoid the problem, according to a study.
It’s now thought that in many cases, cancer cells disseminate from the primary tumor site early on and lie dormant for long periods rather than only venturing out from primary tumors at an advanced stage.
Recent insights, such as the recognition that disseminated cancer cells can lie dormant for years before seeding secondary tumors, suggest novel strategies for fighting metastatic disease.
From his student days in veterinary medicine in Ethiopia to running a lab on metastasis at MD Anderson Cancer Center, Debeb has a passion for understanding how living things work.
A physician and neurobiologist at the Rockefeller University who specialized in addiction research, Kreek was best known for her work on developing the treatment for heroin addiction.
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
Healthy people put through high-intensity interval training, or HIIT, displayed insulin resistance and mitochondrial dysfunction after working out excessively.
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Two new papers describe the generation of so-called blastoids, which could avoid the use of embryonic cells and make studying early human development much more accessible.
Stronger interferon production, greater T cell activation, and increased susceptibility to autoimmunity are just some of the ways that females seem to differ from males.
Males and females show differences in gene expression, cell activation, and antibody production in response to some viral infections, but whether these influence COVID-19 outcomes is still unclear.