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Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
A needle drawing up fluid from an unlabeled vial.
Cancer Vaccination as a Promising New Treatment Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 10+ min read
Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.
A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Amanda Heidt | Mar 24, 2022 | 3 min read
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
Tumor microbiome composite
Could Cancer’s Microbiome Help Diagnose and Treat the Disease?
Jef Akst | Mar 14, 2022 | 10+ min read
A growing appreciation of the bacterial assemblages that live within tumors has researchers striving to understand and capitalize on their role.
The Breakthrough Prize ?Trophy
2024 Breakthrough Prizes in Life Sciences
Danielle Gerhard, PhD | Sep 14, 2023 | 10 min read
This year’s Breakthrough Prizes honor advances in CAR T cancer therapies, cystic fibrosis, and Parkinson’s disease.
Week in Review: March 3–7
Tracy Vence | Mar 7, 2014 | 3 min read
The gene behind a butterfly’s mimicry; the evolution of adipose fins; bacteria and bowel cancer; plants lacking plastid genomes
Bacteria as Living Microrobots to Fight Cancer
Simone Schuerle and Tal Danino | Apr 1, 2020 | 10+ min read
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology.
Novelty Activates a Long Noncoding RNA for Spatial Learning in Mice
Shelby Bradford, PhD | Feb 6, 2024 | 4 min read
Genes activated in new environments include those used during development.
Image shows photorhabdus virulence cassettes (green) binding to insect cells (blue) prior to injection of payload proteins. 
Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells
Rohini Subrahmanyam, PhD | Apr 20, 2023 | 4 min read
Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.

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