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Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Cultural Revolution: Mycoplasma Testing Kits and Services
Linda Raab | Oct 10, 1999 | 9 min read
Date: October 11, 1999Mycoplasma Detection Kits Mycoplasma Testing Services Most scientists who engage in cell culture find it such a chore to split cells on a regular basis that conscientious habits like routine testing for mycoplasma remain an unrealized ideal. Although mycoplasma contamination can potentially foil the most crucial of experiments, one may argue that mycoplasma testing is expensive, time consuming, or complicated. Fortunately, times are changing. Several companies have develop
Molecular Multitasking
Carina Storrs | Aug 1, 2013 | 6 min read
Commercial kits use fluorescent beads to probe dozens of cytokines in one reaction.
The Death of a Cell
Laura Defrancesco | Dec 7, 1997 | 3 min read
Another characteristic of apoptotic cells that can be exploited in this death quest is the appearance of phosphatidylserine (PS) on the outer surface of the membrane. Annexin V binds with high affinity to PS and can be used to spotlight dying cells. Fourteen companies offer Annexin V with a variety of tags and detectors attached that can be used immunohistochemically or with the flow cytometer (Alexis, BioWhittaker, Boehringer Mannheim, Chemicon, CLONTECH, Immunotech, Genzyme Diagnostics, Kamiy
2017 Top 10 Innovations
The Scientist | Dec 1, 2017 | 10+ min read
From single-cell analysis to whole-genome sequencing, this year's best new products shine on many levels.
Choosing the Best Reporter Assay
Hillary Sussman | Jul 22, 2001 | 10+ min read
Suppliers of Reporter Assay Screening Systems Courtesy of Applied BiosystemsTarget practice: Researchers can employ reporter assays to study a variety of cellular processes. Rarely is the product of a gene readily distinguishable from the myriad mRNA and protein complements that exist in a cell at any point in time. But researchers can skirt this obstacle by placing a "reporter gene" under the same controls as the gene of interest. Reporter genes have easily measurable phenotypes that form th
Antibodies Making Their Way From The Clinic To The Research Lab
Holly Ahern | Sep 17, 1995 | 10 min read
if (n == null) The Scientist - The Immune Response The Scientist 9[18]:18, Sep. 18, 1995 Tools The Immune Response By Holly Ahern Imagine that you've just cloned a gene for a bacterial enzyme with unique structural properties and you want to find out more about it. What natural role does the enzyme play, you wonder, and do organisms other than bacteria produce it? To answer these questions, you could screen countless genomic libraries for clones bearing si
DNA, RNA Probes Help Investigators Narrow The Search For Genes
Holly Ahern | Nov 26, 1995 | 10+ min read
For Genes Author: Holly Ahern For a geneticist, pinpointing a mutation in a human gene that might be responsible for an inherited disease can be likened to the proverbial search for a needle in a haystack. While mo-lecular biologists sift through the 3 billion base pairs in the human genome in search of disease-causing genes, other scientists choose to approach the problem from the perspective of the mouse, a model system for mammal research. Because mice and humans are members of the same gr
Death Watch II: Caspases and Apoptosis
Jorge Cortese | Jun 24, 2001 | 10 min read
Caspase Related Reagents Courtesy of Bingren Hu, Queen's Medical Center, Hawaii. Provided by Cell Signaling TechnologyConfocal micrograph of double immunostaining for cleaved caspase-3 (green) and propidium iodide (red) in newborn rat brain tissue. This section shows control and transient cerebral ischemia. Editor's Note: This is the second article in our two-part series on cell death. The first part: J. Cortese, "Death watch I: Cytotoxicity detection," The Scientist, 15[5]:26, March 5, 2001.

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