The Sloan Kettering researcher used mutagenic screening to probe genes and molecular pathways, including Toll and Hedgehog, essential to development in fruit flies and mice.
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Studying how neural crest cells journey through the embryo, this Caltech developmental biologist has revealed how they form major cell types, including peripheral neurons, bone, and smooth muscle.