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image: A Database of Genetic Differences Among Lab Mice

A Database of Genetic Differences Among Lab Mice

By | August 7, 2017

Researchers have catalogued mutations in the coding regions of 36 of the most important mouse strains.

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image: Engineered Human Liver Tissue Grows in Mice

Engineered Human Liver Tissue Grows in Mice

By | July 19, 2017

Tissue “seeds” made up of three cell types and patterned onto a scaffold develop into complex structures with some organ function, researchers show.

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The International Mouse Phenotyping Consortium aims to characterize the entire mouse genome, starting first with more than 3,300 genes. 

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Mouse experiments indicate that, contrary to observations in pregnant women, reactive oxygen species contribute to normal placental development.

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Discrepancies in the populations’ immune systems suggest murine models of immunological disorders possess more limitations than scientists had appreciated.

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image: Upgraded Photoswitch for Vision Repair

Upgraded Photoswitch for Vision Repair

By | April 13, 2017

Researchers improve on a technique to use a light-stimulated small molecule to confer longer-term photosensitivity to the retinal cells of blind mice.

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image: CRISPR Corrects Duchenne-Causing Mutations

CRISPR Corrects Duchenne-Causing Mutations

By | April 12, 2017

Using CRISPR-Cpf1 gene editing, researchers have fixed mutations that cause a form of muscular dystrophy in cultured human cardiomyocytes and a mouse model.

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image: Opinion: Canine Models for Alzheimer’s

Opinion: Canine Models for Alzheimer’s

By | March 1, 2017

For research on drugs to treat neurodegenerative diseases, dogs offer a better predictor of clinical outcomes. 

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image: Q&A: Zika Damages Mouse Testes, Reduces Fertility

Q&A: Zika Damages Mouse Testes, Reduces Fertility

By | October 31, 2016

Michael Diamond of the Washington University School of Medicine in St. Louis and colleagues tracked the virus in the male mouse reproductive tract over several weeks.

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image: Study: Enriched Housing Changes Murine T Cells

Study: Enriched Housing Changes Murine T Cells

By | October 3, 2016

Mice that live in a more-stimulating environment for two weeks appear to develop a more-inflammatory immune state that might help protect the animals against infection. 

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