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» drug resistance and developmental biology

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image: Signaling Resistance

Signaling Resistance

By | April 1, 2015

Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.

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image: Toggling Between Life and Death

Toggling Between Life and Death

By | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

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image: From Many, One

From Many, One

By | April 1, 2015

Diverse mammals, including humans, have been found to carry distinct genomes in their cells. What does such genetic chimerism mean for health and disease?

4 Comments

image: Short, Strong Signals

Short, Strong Signals

By | March 25, 2015

Methylation increases both the activity and instability of the signaling protein Notch.

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image: Medical Equipment May Spread Superbug

Medical Equipment May Spread Superbug

By | February 20, 2015

Drug-resistant bacteria have spread in a Los Angeles hospital, perhaps from contaminated endoscopes.

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image: Anticipating Resistance

Anticipating Resistance

By | February 16, 2015

Using computational algorithms and experimental evolution, researchers are predicting antimicrobial-resistance patterns to improve drug design. 

3 Comments

image: Understanding Antimalarial Drug Resistance

Understanding Antimalarial Drug Resistance

By | January 21, 2015

Researchers identify mutations associated with resistance to the frontline antimalarial drug artemisinin.

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image: Tracking Tuberculosis Over Time

Tracking Tuberculosis Over Time

By | January 19, 2015

Genomic analysis of a multidrug-resistant lineage pinpoints historical correlations with human events.

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image: Fertility Treatment Fallout

Fertility Treatment Fallout

By | January 1, 2015

Mouse offspring conceived by in vitro fertilization are metabolically different from naturally conceived mice.

7 Comments

image: NIH Study Canceled

NIH Study Canceled

By | December 15, 2014

The National Institutes of Health shutters its initiative to track the health of 100,000 children through adulthood.

3 Comments

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