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tag conservation biology immunology

Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
Those We Lost in 2018
Ashley Yeager | Dec 26, 2018 | 10+ min read
The scientific community said goodbye to a number of leading researchers this year.
Targeting Antibiotic-Resistant Bacteria with CRISPR and Phages
Anna Azvolinsky | May 18, 2015 | 3 min read
Researchers develop a CRISPR-based, two-phage system that sensitizes resistant bacteria to antibiotics and selectively kills any remaining drug-resistant bugs. 
Ultimate Abs
Deborah Wilkinson | Apr 16, 2000 | 10+ min read
Antibody Purification Reagents The immune response is often exploited to produce those remarkably useful affinity reagents known as antibodies. Today's biological and biomedical laboratories employ an array of different immunochemical techniques. For example, a specific antibody can be harnessed to screen for the presence of its respective antigen, quantify the amount of antigen in a given sample, determine the antigen's subcellular location, isolate the antigen from complex mixtures, and sear
Mafia Wars
Jef Akst | May 31, 2010 | 10+ min read
An increasing amount of data is showing that the cellular battle between pathogens and hosts needs much more than a simple military metaphor to describe it—think undercover infiltration, front organizations, and forced suicide.
Probing Protein Interactions
Laura Defrancesco | Apr 14, 2002 | 8 min read
The challenge of proteomics is personified in the Greek god, Proteus. The keeper of all knowledge, past, present and future, Proteus would not give up any information easily; even while held down, he would struggle and assume different forms before giving anything up. Remarkably, proteomics, and proteins for that matter, were not named after Proteus, but the imagery could not be more fitting. It's still anyone's guess what the final gene count will be in the human genome, let alone the total nu
How Well Do Mice Model Humans?
Ricki Lewis | Oct 25, 1998 | 8 min read
STRIKING RESEMBLANCE: James Croom, who studies Down syndrome mice at North Carolina State University, says the animals are providing valuable information useful to humans. When a page-one article in the May 3, 1998, Sunday New York Times portrayed angiogenesis inhibitors that fight cancer in mice as being possible just around the corner for humans, criticism for raising false hopes erupted. Merely 10 weeks later, however, when researchers from the University of Hawaii reported cloning the fi
Articles Alert
Simon Silver | Jul 8, 1990 | 7 min read
The Scientist has asked a group of experts to comment periodically upon recent articles that they have found noteworthy. Their selections, presented herein every issue, are neither endorsements of content nor the result of systematic searching. Rather, the list represents personal choices of articles the columnists believe the scientific community as a whole may also find interesting. Reprints of any articles cited here may be ordered through The Genuine Article, 3501 Market St., Philadelphia,

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