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Genomic analysis of an oak tree that lived during Napoleon’s time supports the idea that plants somehow avoid the accumulation of mutations in their stem cells.

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The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials. 

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image: Cell Lines Gain Cancer-Related Mutations

Cell Lines Gain Cancer-Related Mutations

By | April 27, 2017

A screen of human embryonic stem cell lines finds several that accumulated changes in the gene TP53, including aberrations commonly seen in cancer.

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image: CRISPR-Based Nucleic Acid Test Debuts

CRISPR-Based Nucleic Acid Test Debuts

By | April 13, 2017

SHERLOCK combines CRISPR-Cas13a with isothermal RNA amplification to detect RNA and DNA with single-base specificity.

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image: DNA Replication Errors Contribute to Cancer Risk

DNA Replication Errors Contribute to Cancer Risk

By | March 23, 2017

A follow-up study confirms that random mutations acquired during normal stem cell division likely play a major role in cancer incidence.

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image: Mutation vs. Mutation

Mutation vs. Mutation

By | November 3, 2016

Yeast study finds many instances—often among related genes—in which a mutation in one gene cancels the negative effects of a mutation in another.

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image: Largest Human Genetic Variation Repository Yet

Largest Human Genetic Variation Repository Yet

By | August 17, 2016

An open-access catalog of tens of thousands of human exome sequences highlights the power of a very large genomic dataset in pinpointing genes linked to rare diseases. 

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image: “Redhead” Gene Variant Boosts Melanoma Risk

“Redhead” Gene Variant Boosts Melanoma Risk

By | July 12, 2016

People without red hair who possess the variant are also more likely to develop this form of skin cancer, researchers report.

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image: Immune Defect Detected in Knockout Mice

Immune Defect Detected in Knockout Mice

By | May 20, 2016

Researchers have identified a mutation in a commonly used commercial mouse strain that could impact experimental results.

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image: Advances in Genome Editing

Advances in Genome Editing

By | April 20, 2016

Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.

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