mutations

Researchers identify deletions in the N-terminal domain of the spike protein that allow the coronavirus to avoid antibody neutralization and that may contribute to the emergence of new variants.

A preprint casts doubt on vaccine effectiveness in light of certain mutations in the 501Y.V2 variant that emerged from South Africa.

Whole-genome sequencing reveals a wide range of UV-induced DNA changes in human skin cells, and lighter skin collects more mutations, sometimes to “sky high” levels.

DNA replication errors during cell division cause monozygotic twins to diverge from each other even during the earliest stages of development, a new study finds.

Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA.

The small number of genetic differences between the original strain of the novel coronavirus from Wuhan and those currently circulating in the US population indicates that a vaccine may likely offer lasting immunity.

Researchers determined that the incidence of new genetic mutations is comparable in people of different ancestries, but lower in Amish people.

Colorectal tumor cells limit their DNA repair in response to a targeted therapy, giving them a greater chance to develop resistance to the drug.

Autophagy may keep cell division in check to help protect against cancer-causing DNA damage.

Genetic mutations create lab mice with unusually long and short tails.

The disease is caused by mutations in a single gene. Can gene editing fix the problem?

The UCLA geneticist examines how defects in a histone protein lead to symptoms throughout the body.

The Stanford University human geneticist identified the genes and genomic abnormalities underlying numerous rare diseases, including Rett  syndrome, and advanced the field of molecular diagnostics. 

Clinical analyses of patients’ gene sequences are helping to provide answers where none were available before.

Last year, researchers claimed the gene-editing method had accuracy issues, but a new whole-genome sequencing analysis by the same team finds otherwise.

A device dubbed the “mother machine” enables real-time observation of mutagenesis in single bacterial cells.  

The agency gave personal genomics company 23andMe the green light to screen samples for breast cancer–related genetic mutations.

Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.

Mutations in both copies of SERPINE1 can result in blood clotting disorders, but carriers might enjoy longer lifespan and health benefits.