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mutations

CRISPR for Cures?
Kerry Grens | Dec 5, 2013 | 3 min read
Studies in mice and human stem cells demonstrate that the genome-editing technique CRISPR can correct disease-causing mutations.
Decoding Breast Cancer Drug Resistance
Ed Yong | Nov 3, 2013 | 4 min read
Common mutations in metastasized breast tumors suggest how the cancer can develop resistance to frontline drugs.
Different Cancers, Same Mutations
Ruth Williams | Sep 26, 2013 | 3 min read
Scientists document common genetic alterations in cancers of different origins.
Gene Therapy Coming of Age?
Dan Cossins | Jul 11, 2013 | 4 min read
Using lentiviral vectors to replace mutated genes in blood stem cells, scientists successfully treat two rare diseases apparently without causing harmful side effects.
Identifying Spurious Cancer Mutations
Dan Cossins | Jun 19, 2013 | 2 min read
Researchers reveal why analyses of cancer-causing mutations are riddled with false positives and demonstrate a new approach that eliminates the problem.
Did Inbreeding Royals Evolve?
Dan Cossins | Apr 22, 2013 | 2 min read
A new study suggests that in the Spanish Habsburg royal family, natural selection may have diminished the most harmful effects of inbreeding.
Fast Worms
Kerry Grens | Jan 1, 2013 | 2 min read
A microfluidic device scans individual C. elegans for abnormal traits and sorts wild-type animals from mutants.
Kartik Chandran: Chemistry Kid
Jef Akst | Sep 1, 2012 | 3 min read
Associate Professor, Department of Microbiology & Immunology, Albert Einstein College of Medicine, Age: 38
Sweet Smell of Success
Karen Hopkin | Jul 1, 2012 | 9 min read
With persistence and pluck, Leslie Vosshall managed to snatch insect odorant receptors from the jaws of experimental defeat.
Fewer Mutations in Tumor Mitochondria
Hayley Dunning | Jun 7, 2012 | 3 min read
Contrary to existing dogma, colon cancer cell mitochondria carry fewer mutations than mitochondria of normal body cells.
Hacking the Genome
Karen Hopkin | Jun 1, 2012 | 9 min read
In pondering genome structure and function, evolutionary geneticist Laurence Hurst has arrived at some unanticipated conclusions about how natural selection has molded our DNA.
Ginormous Genome
Sabrina Richards | May 1, 2012 | 1 min read
Researchers find organisms with huge genomes with high mutation rates, overturning a common expectation in evolutionary biology.
Combing the Cancer Genome
Carina Storrs | Mar 1, 2012 | 8 min read
A guided tour through the main online resources for analyzing cancer genomics data
Double the Mutations
Hannah Waters | Jan 30, 2012 | 2 min read
Irradiated sperm of young male mice induce mutations in eggs upon fertilization, a phenomenon that may pose risks for the children of cancer survivors.
The Tradeoff of Stress
Ruth Williams | Dec 15, 2011 | 3 min read
For nematode worms, a bigger stress response means a healthier, longer life, but fewer babies.
Top 7 in Evolutionary Biology
Jef Akst | Nov 29, 2011 | 3 min read
A snapshot of the most highly ranked articles in evolutionary biology and related areas, from Faculty of 1000
Schizophrenia Genetics Revealed
Jef Akst | Aug 8, 2011 | 1 min read
Researchers identify new mutations in schizophrenia patients without a family history of the disease.
Deconstructing the Mosaic Brain
Tom Curran | Aug 1, 2011 | 5 min read
Sequencing the DNA of individual neurons is a way to dissect the genes underlying major neurological and psychological disorders.
Our own 60 mutations
Jef Akst | Jun 15, 2011 | 1 min read
New estimates of human mutation suggest that each of us harbor approximately 60 novel genetic mutations.
First, Do No Harmā€¦
Jim Woodgett | Jun 9, 2011 | 5 min read
Is DNA damage an inevitable consequence of epigenetic reprogramming?
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