immunity, genetics & genomics

In the first clinical study of its kind in the US, researchers used CRISPR to modify CAR T cells to make them more potent against cancer, but the clinical benefits are unknown.

The latest CRISPR deactivators to be discovered turn off the Streptococcus pyogenes Cas9 widely used in genome editing.

The makeup of an individual’s microbiome correlates with genetic variation in immunity-related pathways, a study shows.

Arabidopsis thaliana defense hormones shape the plant’s root microbiome. 

A smaller Cas9 protein enables in vivo genome engineering via viral vectors.

Protein appears to protect stressed neurons; vitamin A’s lifelong effects on immunity; stem cells influenced by substrates; supercharged photosynthesis through nanotechnology

Federal stem cell regulations vary; Salmonella exploit host immune system; microglia help maintain synaptic connections; prosthesis re-creates feeling of touch

Infant immune systems suppressed; why tissues are tough to freeze; silencing one gene causes secondary effects; estrogen’s role in drug-resistant breast cancer