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Chromosome with gold band
Immunity Genes May Play a Role in Down Syndrome
Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.
Immunity Genes May Play a Role in Down Syndrome
Immunity Genes May Play a Role in Down Syndrome

Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.

Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.

immunology, developmental biology

Infographic: Maternal Microbiota Has Lasting Effects on Offspring
Carolyn A. Thomson and Kathy D. McCoy | Aug 1, 2021 | 3 min read
Work in rodents shows that the bacteria living in a mother’s gut can produce immunomodulatory metabolites and influence the production of maternal antibodies—both of which can affect her offspring’s development.
The Role of Mom’s Microbes During Pregnancy
Carolyn A. Thomson and Kathy D. McCoy | Aug 1, 2021 | 10+ min read
Bacteria in the gut influence the production of antibodies and themselves secrete metabolites. In a pregnant woman, these compounds may influence immune development of her fetus.
A scanning electron micrograph of a fetal gut, pseudocolored in yellow and blue
Microbes in Human Fetuses Spur Immune Development
Abby Olena, PhD | Jun 3, 2021 | 4 min read
Researchers identify live bacteria in fetal guts, skin, lungs, and placentas that activate memory T cells, indicating that early exposure to microbes could help educate the developing immune system.
Sample Preparation with Single Cell Multiomics: Simultaneous Epigenomic and Transcriptomic Profiling from the Same Cell
The Scientist | Sep 30, 2020 | 1 min read
In this webinar brought to you by 10x Genomics, experts will discuss how to successfully prepare nuclei suspensions for Single Cell Multiome ATAC + Gene Expression experiments.
Getting Started with Single Cell Multiomics: Simultaneous Epigenomic and Transcriptomic Profiling from the Same Cell
The Scientist | Sep 15, 2020 | 1 min read
In this webinar brought to you by 10x Genomics, experts will discuss tips for running Chromium Single Cell Multiome ATAC + Gene Expression experiments in your lab.
Federal Health Agency Revokes Contract with Fetal Tissue Supplier
Sukanya Charuchandra | Sep 26, 2018 | 2 min read
Health and Human Services plans to review all research involving human fetal tissue.
Amazonians Offer Clues to Human Childhood Development
Shawna Williams | Jul 1, 2018 | 4 min read
A study of Shuar children in Ecuador provides a window into how the human body responds to infection in the sorts of conditions that shaped our species’ evolution.
Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
Macrophages Are the Ultimate Multitaskers
Claire Asher | Oct 1, 2017 | 10+ min read
From guiding branching neurons in the developing brain to maintaining a healthy heartbeat, there seems to be no job that the immune cells can’t tackle.
Infographic: Macrophages Around the Body
Claire Asher | Sep 30, 2017 | 2 min read
In addition to circulating in the blood as immune sentinels, macrophages play specialized roles in different organs around the body.
Fetal Immune System Operational by Second Trimester
Abby Olena, PhD | Jun 14, 2017 | 3 min read
Research shows that human immunity develops much earlier than previously thought, but functions differently in adults.
Macrophages Physically Relay Signals Between Cell Types
Catherine Offord | May 1, 2017 | 3 min read
Time-lapse imaging shows the immune cells transferring chemical signals during pigment pattern formation in developing zebrafish.
Infographic: How the Zebrafish Got Its Stripes
Catherine Offord | Apr 30, 2017 | 1 min read
Immune cells called macrophages shuttle cellular messages in the skin.
Further Support for Early-Life Allergen Exposure
Jef Akst | Sep 20, 2016 | 3 min read
Egg and peanut consumption during infancy is linked to lower risk of allergy to those foods later in life, according to a meta-analysis.
Guts and Glory
Anna Azvolinsky | Apr 1, 2016 | 9 min read
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
Rethinking Lymphatic Development
Amanda B. Keener | Aug 1, 2015 | 9 min read
Four studies identify alternative origins for cells of the developing lymphatic system, challenging the long-standing view that they all come from veins.
Week in Review, June 17–21
Jef Akst | Jun 21, 2013 | 4 min read
On the gene patent decision; a high-res human brain model; bats’ influence on moths mating calls; toxicants threaten brain health; platelet-driven immunity
Flow Cytometry for the Masses
Richard P. Grant | Dec 1, 2011 | 2 min read
Tagging antibodies with rare earth metals instead of fluorescent molecules turns a veteran technique into a high-throughput powerhouse.
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