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tag transcription factors culture evolution microbiology

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How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
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What Does It Look Like to “Turn On” a Gene?
Alla Katsnelson, Casey Rentz, and Knowable Magazine | May 3, 2019 | 8 min read
Only recently have scientists directly witnessed this most pivotal of events in biology, thanks to new technology that allows them to observe the process in living cells. It’s teaching them a lot.
Updated Sept 1
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Follow the Coronavirus Outbreak
The Scientist | Feb 20, 2020 | 10+ min read
Saliva tests screen staff and students at University of Illinois; Study ranks species most susceptible to SARS-CoV-2 infection; COVID-19 clinical trials test drugs that inhibit kinin system
A Bacterial Messenger Molecule Extends Healthspan
Sandhya Sekar | Aug 27, 2017 | 3 min read
E. coli that make indoles protect older worms, flies, and mice from frailty. 
Sharing the Bounty
Michelle G. Rooks and Wendy S. Garrett | Aug 1, 2011 | 10+ min read
Gut bacteria may be the missing piece that explains the connection between diet and cancer risk.
Mining Bacterial Small Molecules
L. Caetano M. Antunes, Julian E. Davies and B. Brett Finlay | Jan 1, 2011 | 10 min read
As much as rainforests or deep-sea vents, the human gut holds rich stores of microbial chemicals that should be mined for their pharmacological potential.
The Language of Bacteria ... and Just About Everything Else
Kendra Rumbaugh | Sep 12, 2004 | 5 min read
FIGURE 1:Courtesy of Kendra RumbaughEukaryotic and prokaryotic signaling molecules have similar functions. Mammalian steroid hormones bind to cognate nuclear hormone receptors; Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone acts as a ligand for the transcriptional activator LasR and is essential for cell-to-cell communication resulting in biofilm formation.Mammals possess sophisticated endocrine networks in which hormonal signals modulate hundreds of biological effects s
Unlikely Heroes
Nicole Johnston | Jun 1, 2003 | 6 min read
Dr. R. Thomas Broker Among model organisms, bacteria hold a unique place, as both models of infection and pathogenesis, and as research tools. More to the point, molecular biology was built upon the cell walls of lowly bacteria: The processes of DNA replication, RNA transcription, and protein translation, not to mention gene regulation, were all worked out in bacteria. Those early studies provided the foundations to understanding the more complex processes in eukaryotes. Despite their relati
The Divine Cytokine
Bob Sinclair | Apr 2, 2000 | 10 min read
Tools for Cytokine Research Companies producing cytokines Courtesy of Alexis CorpCytokine Network Many proteins and peptides affect the growth, identity, and function of eukaryotic cells. Very often their effects are highly pleiotropic, making exact boundaries and distinctions between proteins such as hormones, growth factors, and cytokines difficult to pin down. The result is a nomenclature tangle almost as complex as the regulatory circuits these molecules mediate. Although this treatment of
Human Pluripotent Cells Pass Safety Test
Douglas Steinberg | Sep 1, 2002 | 7 min read
Image: ©2001 MacMillan Publishers Ltd.  PLURIPOTENT-CELL PIPELINE: To obtain embryonic germ cells, researchers culture primordial germ cells (PGCs) dissected from the genital ridge. If left in situ, a PGC develops into spermatozoa or ova after its imprints have been erased and reestablished. Embryonic stem cells come from the blastocyst's inner cell mass. (Reprinted with permission, Nature 414:122-8, 2001) Because the science is hard and the politics mean, progress in understanding

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