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Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.

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image: Exploring the Epigenetics of Ethnicity

Exploring the Epigenetics of Ethnicity

By | January 11, 2017

Researchers attempt to estimate how much of the human genome’s methylation patterns can be attributed to genetic ancestry.

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image: Contributors

Contributors

By | January 1, 2017

Meet some of the people featured in the January 2017 issue of The Scientist.

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image: Pharma Redo

Pharma Redo

By | January 1, 2017

Steve Braun of Cures Within Reach, a nonprofit focused on breathing new life into old medicines, describes the potential benefits of drug repurposing.

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Oncologists have raised concerns about a mouse study that suggests the vaccine for human papillomavirus could cause brain damage.

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image: Mouse Immunology Paper Retracted

Mouse Immunology Paper Retracted

By | December 16, 2016

A finding of misconduct spurs the retraction of a Science paper claiming to have identified a protein in mice that boosted immunity to both viruses and cancer.

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image: Naive T Cells Find Homes in Lymphoid Tissue

Naive T Cells Find Homes in Lymphoid Tissue

By | December 2, 2016

The human lymph nodes and spleen maintain unique, compartmentalized sets of naive T cells well into old age.

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image: Oligonucleotide Therapeutics Near Approval

Oligonucleotide Therapeutics Near Approval

By | December 1, 2016

Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles.

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image: Synthetic Sensors

Synthetic Sensors

By | December 1, 2016

Engineered circuits detect endogenous transcription factors to drive cellular outputs.

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image: Infographic: How to Build a Synthetic Sensor

Infographic: How to Build a Synthetic Sensor

By | December 1, 2016

Scientists designed a genetic sensor-and-readout system, based on detecting a transcription factor, that performs a custom cellular activity.

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