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tag big pharma evolution microbiology

Monitoring Mutations with Microfluidics
Ruth Williams | Mar 15, 2018 | 3 min read
A device dubbed the “mother machine” enables real-time observation of mutagenesis in single bacterial cells.  
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Competition and Cooperation of Cheese Rind Microbes Exposed
Ashley Yeager | Jan 1, 2019 | 4 min read
Transposon mutagenesis give scientists a rare look at the most important interactions within microbial communities.
Capsule Reviews
Bob Grant | Nov 1, 2015 | 3 min read
The Psychology of Overeating, The Hidden Half of Nature, The Death of Cancer, and The Secret of Our Success
The Scientist’s 2019 Gift Guide
Emily Makowski | Dec 13, 2019 | 2 min read
Wishing you a sciency season’s greetings!
monoclonal antibody antibodies sars-cov-2 covid-19 coronavirus pandemic eli lilly receptor binding domain spike protein
First Antibody Trial Launched in COVID-19 Patients
Katarina Zimmer | Jun 2, 2020 | 8 min read
In record time, scientists have gone from harvesting antibodies against SARS-CoV-2 from survivors of coronavirus infections to testing the antibodies’ safety as a drug in humans.
Support for Golgi maturation theory
Juhi Yajnik | May 14, 2006 | 3 min read
Two studies demonstrate that individual Golgi cisternae mature from early to late, potentially resolving long debate
Sons of Next Gen
Tia Ghose | Jun 1, 2012 | 8 min read
New innovations could bring tailored, fast, and cheap sequencing to the masses.
Aptamers Identify Protein Signatures
Ricki Lewis | Apr 1, 2001 | 3 min read
Graphic: Leza BerardoneA technique not deemed "sexy" enough for commercialization a decade ago may finally find its niche in proteomics. SomaLogic Inc. of Boulder, Colo. is pioneering aptamers, which are modified DNA molecules that bind specific proteins in body fluid samples. Aptamers are initially selected for specific binding activities from a huge starting pool, then variants are obtained during subsequent rounds of amplification. The technology builds on the ability of aptamers to bind tena
Automated Colony Pickers Evolve
Helen Dell(hdell@the-scientist.com) | Jul 3, 2005 | 6 min read
Everyone knows that the first genome sequencing projects took years of work and represent the combined product of tens of thousands of individual fragments.

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