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tag proteins developmental biology evolution cell molecular biology

Developmental Biology
The Scientist Staff | Jan 3, 1999 | 3 min read
L.B. Zimmerman, J.M. De Jesús-Escobar, R.M. Harland, "The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4," Cell, 86:599-606, 1996. (Cited in more than 180 papers since publication) Comments by Richard M. Harland, Choh Hao Li professor of biochemistry and molecular biology, University of California, Berkeley Richard M. Harland Researchers had long suspected that the protein noggin's interaction with bone morphogenetic proteins (BMPs) dictated devel
Infusion of Artificial Intelligence in Biology
Meenakshi Prabhune, PhD | Feb 23, 2024 | 10 min read
With deep learning methods revolutionizing life sciences, researchers bet on de novo proteins and cell mapping models to deliver customized precision medicines.
Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
Developmental Biology
The Scientist Staff | Jan 3, 1999 | 3 min read
S. Piccolo, Y. Sasai, B. Lu, E.M. De Robertis, "Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4," Cell, 86:589-98, 1996. (Cited in more than 170 papers since publication) Comments by Eddy M. De Robertis, Investigator, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles Eddy M. De Robertis In 1924, two scientists identified a small group of embryonic cells that tell their neighbor
Developmental Biology
The Scientist Staff | Apr 1, 1996 | 3 min read
Edited by Karen Young Kreeger H. Roelink, A. Augsburger, J. Heemskerk, V. Korzh, S. Norlin, A. Ruiz i Altaba, Y. Tanabe, M. Placzek, T. Edlund, T.M. Jessell, J. Dodd, "Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord," Cell, 76:761-75, 1994. (Cited in nearly 90 publications as of February 1996) Comments by Henk Roelink, University of Washington SIGNALS FROM SONIC HEDGEHOG: Using cDNA, University of Washington's Henk Roelink and col
Molecular Biology
The Scientist Staff | Feb 17, 1991 | 3 min read
R.J. Bandziulis, M.S. Swanson, G. Dreyfuss, "RNA-binding proteins as developmental regulators," Genes and Development, 3, 431-7, April 1989. Gideon Dreyfuss (University of Pennsylvania School of Medicine, Philadelphia): "Protein structural comparisons led to the discovery of identifying and unifying features shared by RNA-binding proteins of the nucleus and cytoplasm. Many of these ribonucleoproteins contain an RNA-binding domain (RBD) of approximately 90 amino acids. This amino acid sequence
Developmental Biology
The Scientist Staff | Feb 1, 1999 | 6 min read
Edited by: Paul Smaglik P. Carmeliet, V. Ferreira, G. Breier, S. Pollefeyt, L. Kieckens, M. Gertsenstein, M. Fahrig, A. Vandenhoeck, K. Harpal, C. Eberhardt, C. Declercq, J. Pawling, L. Moons, D. Collen, W. Risau, A. Nagy, "Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele," Nature, 380:435-9, 1996. (Cited in more than 235 papers since publication) Comments by Andras Nagy, senior staff scientist, Mount Sinai Hospital, Samuel Lunenfeld Research Institute, To
MOLECULAR BIOLOGY
Paris | Jul 19, 1992 | 1 min read
Michel Philippe (Universite de Rennes, Rennes Cédex, France): "In yeast, two critical points of the cell cycle (Start and G1/S) are regulated by the same protein. This protein, called p34cdc2, is coded by the genes cdc2 in Schizzosaccharomyces pombe and CDC28 in Saccharomyces cerevisiae. By complementation of yeast mutants, proteins from higher eucaryotes homologous to cdc2 have been cloned. Moreover, p34cdc2 has been shown to be one of the main components of the well-known M-phase promotin
Molecular Biology
The Scientist Staff | Feb 3, 1991 | 3 min read
T. Hai, F. Liu, W.J. Coukos, M.R. Green, "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers," Genes and Development, 3, 2083-90, December 1989. Michael R. Green (University of Massachusetts Medical Center, Worcester, Mass.): "I suspect that this paper may have attracted more than the usual attention because it is relevant to several research areas, and some of the results were unexpected. We and others had bee
Molecular Biology
The Scientist Staff | Jan 19, 1992 | 1 min read
S. Ghosh, A.M. Gifford, L.R. Riviere, P. Tempst, et al., "Cloning of the p50 DNA binding subunit of NF-kB: homology to rel and dorsal," Cell, 62:1019-29, 1990. Sanker Ghosh (Yale University School of Medicine; formerly at Whitehead Institute for Biomedical Research, Cambridge, Mass.): "NF-kB is a transcription factor that is widely used for the inducible expression of a large number of cellular and viral genes. This has resulted in the study of NF-kB by researchers interested in diverse areas

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