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tag mars genetics genomics

2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
A fruit bat in the hands of a researcher
How an Early Warning Radar Could Prevent Future Pandemics
Amos Zeeberg, Undark | Feb 27, 2023 | 8 min read
Metagenomic sequencing can help detect unknown pathogens, but its widespread use faces challenges.
Pufferfish Genomes Probe Human Genes
Ricki Lewis | Mar 17, 2002 | 7 min read
It may be humbling to think that humans have much in common with pufferfish, but at the genome level, the two are practically kissing cousins. "In terms of gene complement, we are at least 90% similar—probably higher. There are big differences in gene expression levels and alternate transcripts, but if you're talking about diversity, number and types of proteins, then it's pretty difficult to tell us apart," says Greg Elgar, group leader of the Fugu genome project at the Medical Research C
Will Genomics Spoil Gene Ownership?
Douglas Steinberg | Sep 3, 2000 | 8 min read
Consider a scenario for the year 2002: Using commercially available software, bioprospector "Craig Collins" spends a day scavenging the Human Genome Project (HGP) database for the alternatively spliced genes prized by Wall Street. He enters the sequences of several candidate genes into a software package that prints out the likely functions of their protein products. One protein looks like it could be pharmaceutical paydirt, so he isolates the corresponding cDNA, inserts it into a vector, then
A Test Bed for Budding Technologies
Aileen Constans | Jul 4, 2004 | 6 min read
DELETION BY DESIGN:Courtesy of Guci GiaeverThe deletion cassette module used to delete each yeast gene contains two 74-basepair tags upstream and downstream (UPTAG and DNTAG) of the KanMX gene, which confers resistance to the drug geneticin. UPTAG and DNTAG contain 18 basepairs of genomic sequence to flank the yeast's open reading frame, and U1 and U2, or D1 and D2 PCR primers for amplifying a unique 20-basepair TAG region-the so-called molecular barcode. A second round of PCR adds 45 base-pairs
DNA Software Takes The Drudgery Out Of Molecular Biology
Ricki Lewis | Sep 15, 1991 | 8 min read
Author: RICKI LEWIS, p.23 It is expected to take some 15 years to determine the sequence of the 3 billion base pairs that make up the human genome--roughly 550,000 base pairs per day. An analytical task of this magnitude would have been unthinkable just a few years ago, but today's rapidly advancing computer technology has made the international effort to sequence the human genome possible. C.B.S. Scientific Co. Inc. P.O. Box 856 Del Mar, Calif. 92014 Phone: (619) 755-4959 Fax: (619) 755-
David Botstein
The Scientist Staff | Jul 27, 2003 | 4 min read
First Person | David Botstein Courtesy of Frank Wojciechowski At the age of 60, David Botstein, microarray and genetics pioneer, is learning to play the cello. As a young man, Botstein seriously considered being a musician, but he knew the talent just wasn't there. "I did play the violin, badly," he admits. Yet his love of music is so ingrained--his brother, Leon, is music director for the American Symphony Orchestra--that even as an undergraduate at Harvard, he "ran with the musicians."
An Ocean of Viruses
Joshua S. Weitz and Steven W. Wilhelm | Jul 1, 2013 | 10+ min read
Viruses abound in the world’s oceans, yet researchers are only beginning to understand how they affect life and chemistry from the water’s surface to the sea floor.
Notebook
The Scientist Staff | Mar 2, 1997 | 8 min read
Monday mornings can be tough, even if you're Bill Gates. The head of Redmond, Wash.-based Microsoft Corp. ran into a few glitches at a presentation he was giving at the annual meeting of the American Association for the Advancement of Science (AAAS) in Seattle. In the middle of a demonstration on February 17 aimed at showing how Web browsers and E-mail will soon merge, the modem connection failed. A computer-vision demonstration by a Microsoft researcher didn't work, either. Then, during a ques
The Rise of Biological Databases
Jennifer Fisher Wilson | Mar 17, 2002 | 6 min read
For this article, Jennifer Fisher Wilson interviewed Richard J. Roberts, chief U.S. editor of Nucleic Acids Research; Alex Bateman, group leader of Pfam at the Sanger Institute in Cambridge; and Peer Bork, head of the European Molecular Biology Laboratory's SMART team in Heidelberg, Germany, for SMART. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. All four Hot Papers were published Jan

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