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Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

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image: Protein or Perish

Protein or Perish

By | September 1, 2016

A bacteriophage must evolve certain variants of a protein or die.

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image: What Sensory Receptors Do Outside of Sense Organs

What Sensory Receptors Do Outside of Sense Organs

By | September 1, 2016

Odor, taste, and light receptors are present in many different parts of the body, and they have surprisingly diverse functions.

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image: That Other CRISPR Patent Dispute

That Other CRISPR Patent Dispute

By | August 31, 2016

The Broad Institute and Rockefeller University disagree over which scientists should be named as inventors on certain patents involving the gene-editing technology.

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image: One Receptor, Two Ligands, Different Responses

One Receptor, Two Ligands, Different Responses

By | August 31, 2016

Host and bacterial ligands that interact with the same cell-surface receptor induce different activities in human macrophages. 

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image: One Antigen Receptor Induces Two T cell Types

One Antigen Receptor Induces Two T cell Types

By | August 26, 2016

Precursor T cells bearing the same antigen receptor adopt two different fates in mice.

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“Ultimate DISCO” uses a solvent that shrinks whole animals and preserves fluorescence for months.

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Disrupting the light/dark cycles of pregnant mice, researchers observe detrimental effects in the mouths of the animals’ pups.

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image: Student Alleges His Team Didn’t Earn CRISPR Patent

Student Alleges His Team Didn’t Earn CRISPR Patent

By | August 18, 2016

A former researcher at the Broad Institute has suggested the University of California, Berkeley, team deserves credit for inventing the gene-editing technique.

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Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.

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