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Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

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image: Protein or Perish

Protein or Perish

By | September 1, 2016

A bacteriophage must evolve certain variants of a protein or die.

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image: That Other CRISPR Patent Dispute

That Other CRISPR Patent Dispute

By | August 31, 2016

The Broad Institute and Rockefeller University disagree over which scientists should be named as inventors on certain patents involving the gene-editing technology.

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“Ultimate DISCO” uses a solvent that shrinks whole animals and preserves fluorescence for months.

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Disrupting the light/dark cycles of pregnant mice, researchers observe detrimental effects in the mouths of the animals’ pups.

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image: Student Alleges His Team Didn’t Earn CRISPR Patent

Student Alleges His Team Didn’t Earn CRISPR Patent

By | August 18, 2016

A former researcher at the Broad Institute has suggested the University of California, Berkeley, team deserves credit for inventing the gene-editing technique.

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Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.

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image: Antibiotic Resistance Reaches Brazil

Antibiotic Resistance Reaches Brazil

By | August 8, 2016

Scientists detect a colistin-resistance gene in a clinical sample.

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image: Fecal Transplant Pill Fails Trial

Fecal Transplant Pill Fails Trial

By | August 1, 2016

Seres Therapeutics’s microbiome-targeting therapy for recurrent Clostridium difficile infection fails a Phase 2 clinical trial.

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From sequencing bacteriophages to synthesizing bacterial genomes to defining a minimal genome

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