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image: Toggling CRISPR Activity with a Chemical Switch

Toggling CRISPR Activity with a Chemical Switch

By | September 12, 2016

Researchers design a Cas9 enzyme that cuts DNA only in the presence of particular drug.

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image: Group Proposes Strategies to Improve Antibodies

Group Proposes Strategies to Improve Antibodies

By | September 5, 2016

An expert committee encourages reagent providers to adopt one of five methods to validate products.

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image: The History of Optogenetics Revised

The History of Optogenetics Revised

By | September 1, 2016

Credit for the neuroscience technique has largely overlooked the researcher who first demonstrated the method.

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image: Designing In Vitro Models of the Blood-Brain Barrier

Designing In Vitro Models of the Blood-Brain Barrier

By | September 1, 2016

Choosing the right model, be it 3-D or 2-D, requires wading through varied cell sources, cell types, and cell culture conditions.

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image: Promoting Protein Partnerships

Promoting Protein Partnerships

By | September 1, 2016

Scientists generate new protein-protein interactions at an impressive PACE.

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Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

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image: Protein or Perish

Protein or Perish

By | September 1, 2016

A bacteriophage must evolve certain variants of a protein or die.

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image: That Other CRISPR Patent Dispute

That Other CRISPR Patent Dispute

By | August 31, 2016

The Broad Institute and Rockefeller University disagree over which scientists should be named as inventors on certain patents involving the gene-editing technology.

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“Ultimate DISCO” uses a solvent that shrinks whole animals and preserves fluorescence for months.

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Disrupting the light/dark cycles of pregnant mice, researchers observe detrimental effects in the mouths of the animals’ pups.

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