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image: Phosphorylation at the Flick of a Switch

Phosphorylation at the Flick of a Switch

By | May 1, 2017

Incorporating light-controlled dimerization domains into kinases provides tight regulation of these enzymes.

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image: Infographic: Enzymes Controlled by Light

Infographic: Enzymes Controlled by Light

By | May 1, 2017

Custom-designed kinases have built-in switches that act as gatekeepers for the enzymes' active sites.

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Studies of infected rhesus monkeys reveal the virus’s long-term hiding places in the body.

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image: Tissue-Clearing Technique Works on Bone

Tissue-Clearing Technique Works on Bone

By | April 26, 2017

CLARITY made mouse bones transparent while preserving fluorescent labels so researchers could visualize tagged osteoprogenitors.

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image: Scientists Stretch Neurons to Image Fine Structures

Scientists Stretch Neurons to Image Fine Structures

By | April 18, 2017

A double-expansion technique embeds brain tissue in the absorbent material of diapers to stretch out cells for easier visualization.

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image: Contributors

Contributors

By | April 1, 2017

Meet some of the people featured in the April 2017 issue of The Scientist.

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image: Hitting It Out of the Park

Hitting It Out of the Park

By | April 1, 2017

Cancer can be as evasive and slippery as a spitball, but new immunotherapies are starting to connect.

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image: Location, Location, Location

Location, Location, Location

By | April 1, 2017

Since first proposing that a cell’s function and biology depend on its surroundings, Mina Bissell continues to probe the role of the extracellular matrix.

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image: Making CAR T-Cell Therapy Safer

Making CAR T-Cell Therapy Safer

By | April 1, 2017

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment’s toxicity without sacrificing efficacy.

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Measuring PD-L1 levels was a great start. Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too.

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