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tag chronic pain cell molecular biology evolution neuroscience

Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
Senior woman wearing a grey pullover sitting on a bed and holding her back.
Early Inflammation Protects Against Chronic Pain, Study Finds
Alejandra Manjarrez, PhD | May 12, 2022 | 3 min read
Human data and experiments in mice challenge the common use of anti-inflammatory drugs to treat pain.
Image of someone scratching their skin.
A Chronic Itch: Burrowing Beneath the Skin
Brian S. Kim, MD | Sep 8, 2023 | 9 min read
We have barely scratched the surface of itch science and what it indicates about our health.
How Evolution Made the Highveld Mole Rat Impervious to Ant Stings
Shawna Williams | Sep 1, 2019 | 5 min read
Researchers identify changes to a pain receptor and to an ion channel that appear to enable the rodents to colonize otherwise inhospitable burrows.
Glial Ties to Persistent Pain
Mark R. Hutchinson | Jan 1, 2018 | 10 min read
Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.
Photograph of a mouse covering his face with his paw.
Bless You: Mouse Model Reveals Molecular Pathway Behind Sneezing
Amanda Heidt | Oct 1, 2021 | 3 min read
Researchers have identified specific cells and neuropeptides involved in mediating the sneeze response in mice exposed to allergens or chemical irritants such as capsaicin.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Getting at the Molecular Roots of Pain
Karen Hopkin | Jan 3, 1999 | 8 min read
to eliminate difficult-to-control pain while leaving normal sensation intact. Pain is a part of life. Often, a few painkillers and some rest are enough to soothe the scraped knees of childhood and the aches and sprains of adulthood. But for some, pain is not as fleeting or as easily dismissed. The pain from cancer, chemotherapy, arthritis, AIDS, and other diseases can be unrelenting and incapacitating. Some individuals even experience constant, bone-crushing pain for no apparent reason. For man
Targeting Sodium Channels for Pain Relief
Catherine Offord | Jan 1, 2018 | 10+ min read
The race to develop analgesic drugs that inhibit sodium channel NaV1.7 is revealing a complex sensory role for the protein.
Sex Differences in Opioid Analgesia: A Complicated Picture
Catherine Offord | Jan 1, 2018 | 5 min read
Researchers are beginning to tease apart the mechanisms underlying differences in how males and females respond to powerful painkillers.

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