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tag mosquitoes genetics genomics

Reducing Malaria to its Constituent Parts
Eugene Russo | May 23, 2004 | 5 min read
FIRST BITE:Courtesy of CDC/Jim GathanyFemale Anopheles gambiae mosquito feeding.A decade ago, scientists around the world recognized that despite malaria's tremendous disease burden, research on the topic had stagnated. With funding at low levels, robust molecular biology tools numbered few. Today, genome sequences for Plasmodium falciparum, the parasite causing malaria, and for Anopheles gambiae, the mosquito that spreads it, have already fundamentally changed the research landscape. Plasmodium
Alternative Splicing Goes Mainstream
Sam Jaffe | Dec 14, 2003 | 10 min read
In eukaryotic genetics, the one-gene/one-protein concept has, for the most part, breathed its last. Researchers have rallied behind mechanisms such as alternative splicing, which may allow a lowly 30,000-gene genome to produce the dizzying variety of proteins that some believe is necessary to produce beings as complex as humans. Alternative splicing--the post-transcriptional editing process that can result in various mRNAs--was previously seen as an interesting but relatively uncommon sidesh
The Year in Zika
Joshua A. Krisch | Dec 19, 2016 | 4 min read
Scientists advanced the battle against Zika in 2016, conducting basic research to better understand and detect the pathogen while preventing its spread.
How Bacteria Interfere with Insect Reproduction
Ruth Williams | Feb 28, 2017 | 3 min read
Scientists identify the genes responsible for bacteria-controlled sterility in arthropods.
Week in Review: April 24–28
Tracy Vence | Apr 28, 2017 | 2 min read
Where Zika virus persists in monkeys; more-advanced mini brains; artificial womb supports fetal lambs for weeks; cancer mutations in stem cell lines; science marches around the globe
Making Things Grow: Insect Cells, Stem Cells, and Primary Cell Lines All Pose Challenges for Cell Culturists
Laura Defrancesco | Jun 21, 1998 | 5 min read
Date: June 22, 1998 Insect Cell Culture Media, Suppliers of Primary Cell Culture Media Advantages for Protein Expression Studies Since the mid-1950s cultures of insects--cockroaches, fruit flies, and leafhoppers, to name a few--have been the object of quiet study by physiologists and cell biologists. But along came genetic engineering and suddenly insect cultures have been put in the spotlight since they provide advantages over both bacterial and mammalian systems for recombinant protein prod
Stopping the Cycle
Melissa Lee Philips | Aug 1, 2006 | 7 min read
Stefan Kappe's insights into parasite development have already led to a live malaria vaccine for mice.
Research Notes
Eugene Russo | Jun 25, 2000 | 5 min read
Putting Polio to Good Use Add polio to a host of other viral and bacterial foes that, in modified forms, could prove therapeutically beneficial. Although Russian scientists attempted to use polio to treat cancer in the 1960s--unpublished experiments about which little is known--a recent brain cancer study in mice is the first modern-day attempt to harness the power of the virus (M. Gromeier et al., "Intergeneric poliovirus recombinants for the treatment of malignant glioma," Proceedings of the
Cookbook For Eukaryotic Protein Expression: Yeast, Insect, and Plant Expression Systems
Christopher Smith | Nov 8, 1998 | 10+ min read
Date: November 9, 1998Baculovirus Expression Vectors In the recent past, efforts to elucidate the relationship between protein structure and biological function have intensified. Of particular interest is an understanding of the elements of sequence and structure that mediate specific functions. Often the protein of interest is in low abundance in its natural source and can be difficult to purify and/or unstable--subject to proteolytic cleavage or unfolding/non specific refolding during exhaust

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