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tag smart genetics genomics

The Rise of Biological Databases
Jennifer Fisher Wilson | Mar 17, 2002 | 6 min read
For this article, Jennifer Fisher Wilson interviewed Richard J. Roberts, chief U.S. editor of Nucleic Acids Research; Alex Bateman, group leader of Pfam at the Sanger Institute in Cambridge; and Peer Bork, head of the European Molecular Biology Laboratory's SMART team in Heidelberg, Germany, for SMART. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. All four Hot Papers were published Jan
The Alpha Project
Steve Bunk | Feb 23, 2003 | 7 min read
One day, genomic data will be translated into language that can be used to find new diagnostic and therapeutic targets for disease. Computers will mine DNA codes to build nanomachines, and "smart fabrics" will contain sensing capabilities modeled on living things. So says Shankar Shastry, chairman of electrical engineering and computer sciences at the University of California at Berkeley. "Bio is my bet on where the new set of glamour technologies will be," he predicts. But even the small step
David Botstein
The Scientist Staff | Jul 27, 2003 | 4 min read
First Person | David Botstein Courtesy of Frank Wojciechowski At the age of 60, David Botstein, microarray and genetics pioneer, is learning to play the cello. As a young man, Botstein seriously considered being a musician, but he knew the talent just wasn't there. "I did play the violin, badly," he admits. Yet his love of music is so ingrained--his brother, Leon, is music director for the American Symphony Orchestra--that even as an undergraduate at Harvard, he "ran with the musicians."
Premade cDNA Libraries
Sarah Goforth | Apr 15, 2001 | 10 min read
Suppliers of Whole-organism cDNA Libraries Suppliers of Tissue-specific cDNA Libraries The questions of gene function, interaction, and regulation are central to the science of molecular biology. Despite the myriad of new technologies, products, and techniques produced by the genomics revolution, some old standards remain just as useful as ever. One such technology is the cDNA (complementary DNA) library. The sheer number of companies offering premade and custom cDNA libraries and products th
The Array of Today
Jorge Cortese | Sep 3, 2000 | 10 min read
Human Arrays Human Arrays (continued) A 20th century scientist may have spent an entire career studying the function of a single protein, never imagining that one day it would be possible to study every human gene at once. This capability comes in the form of a microarray, a surface collection of immobilized genes that can be simultaneously examined with specialized equipment.1 Many current applications of arrays, also known as biochips, can be used in functional genomics as scientists seek ch
How to Track Cell Lineages As They Develop
Kelly Rae Chi | Dec 1, 2016 | 7 min read
Sequencing and gene-editing advances make tracing a cells journey throughout development easier than ever.
Dial It Up, Dial It Down
Kelly Rae Chi | Mar 1, 2016 | 7 min read
Newer CRISPR tools for manipulating transcription will help unlock noncoding RNA’s many roles.
Top 10 Innovations 2013
The Scientist | Dec 1, 2013 | 10+ min read
The Scientist’s annual competition uncovered a bonanza of interesting technologies that made their way onto the market and into labs this year.
Assays Galore
Lanette Fee | Sep 21, 2003 | 9 min read
Courtesy of BD Biosciences Pharmingen  COLOR CODING: Multiplexed bead-based assays, like BD Biosciences' Cytometric Bead Array (shown), test for multiple analytes in a single vial. The key is in the colors: one hue indicates the bead ID, and the intensity of the second, how much protein has been captured. In today's fast-paced research environment, technologies for speedy, cost-efficient analyses reign supreme. As part of this general trend, techniques for multiplexing, that is, simultan
A Fierce Competitor
Karen Hopkin | Apr 1, 2008 | 7 min read
Christine Jacobs-Wagner's studies of a bacterial species have changed how scientists think about cell shape and polarity.

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