ADVERTISEMENT

404

Not Found

Is this what you were looking for?

tag metabolites culture

High-Throughput Epigenetics Analyses
Jyoti Madhusoodanan | Jan 1, 2018 | 7 min read
Emerging technologies help researchers draw mechanistic links between metabolism and epigenetic modification of DNA.
An illustration of a flask of bacteria, a weighted microscope slide, and two bacteria exchanging materials via nanotubes.
Infographic: Sources of Variation in Bacterial Nanotube Studies
Sruthi S. Balakrishnan | Jun 1, 2021 | 2 min read
Differences in how researchers prepare and image samples can lead to discrepancies in their results.
A scanning electron micrograph of a coculture of E. coli and Acinetobacter baylyi. Nanotubes can be seen extending from the E. coli.
What’s the Deal with Bacterial Nanotubes?
Sruthi S. Balakrishnan | Jun 1, 2021 | 10+ min read
Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
Competition and Cooperation of Cheese Rind Microbes Exposed
Ashley Yeager | Jan 1, 2019 | 4 min read
Transposon mutagenesis give scientists a rare look at the most important interactions within microbial communities.
Bacteria Harbor Geometric “Organelles”
Amber Dance | Dec 1, 2018 | 10+ min read
Microbes, traditionally thought to lack organelles, get a metabolic boost from geometric compartments that act as cauldrons for chemical reactions. Bioengineers are eager to harness the compartments for their own purposes.
Using Mimics to Get Around Antibodiesā€™ Limitations
Devika G. Bansal | Jun 1, 2018 | 7 min read
Synthetic and natural alternatives to traditional antibodies offer more control, specificity, and reproducibility. 
Screening Whole
Kelly Rae Chi | Aug 1, 2009 | 7 min read
By Kelly Rae Chi Screening Whole How to reel in high-throughput results using worms and fish. In the past few years, improvements in imaging and automation techniques have made it easy for researchers to see hundreds of plates of cells partake in every activity from differentiation to apoptosis. But in living and breathing animals, we’re only just beginning to realize the potential of large-scale screens. “To take a whole animal and
Cookbook For Eukaryotic Protein Expression: Yeast, Insect, and Plant Expression Systems
Christopher Smith | Nov 8, 1998 | 10+ min read
Date: November 9, 1998Baculovirus Expression Vectors In the recent past, efforts to elucidate the relationship between protein structure and biological function have intensified. Of particular interest is an understanding of the elements of sequence and structure that mediate specific functions. Often the protein of interest is in low abundance in its natural source and can be difficult to purify and/or unstable--subject to proteolytic cleavage or unfolding/non specific refolding during exhaust
Yeast: An Attractive, Yet Simple Model
Gregory Smutzer | Sep 16, 2001 | 9 min read
Yeast possesses many characteristics that make it especially useful as a model system in the laboratory, including an entirely sequenced genome. Recently, a number of researchers published studies detailing the transition from genome sequencing to functional genomics. Notably, these scientists have developed new high-throughput approaches to the characterization of large numbers of yeast genes. In aggregate, these studies make yeast one of the most well-characterized eukaryotic organisms known.

Run a Search

ADVERTISEMENT