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tag protein stability evolution

Week in Review: June 16–20
Tracy Vence | Jun 20, 2014 | 2 min read
Early Neanderthal evolution; developing antivirals to combat polio; the mouth and skin microbiomes; insect-inspired, flight-stabilizing sensors
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
Top 7 in Genomics & Genetics
Sabrina Richards | Sep 19, 2011 | 3 min read
A snapshot of the most highly ranked articles in genomics, genetics and related areas, from Faculty of 1000
Scientists Debate RNA's Role At Beginning Of Life On Earth
Ricki Lewis | Mar 30, 1997 | 9 min read
Sidebar: RNA's Role at Beginning of Life - For Further Information Before there was life, there were chemicals. The idea that ribonucleic acid (RNA), because of its catalytic capability and multiple roles in protein synthesis, was the chemical that led directly to life is termed the RNA world hypothesis. Although the phrase "RNA world" is generally attributed to Walter Gilbert, Harvard University's Carl M. Loeb University Professor, in a short 1986 paper, the idea of RNA's importance at the beg
Drug Makers on the Apoptotic Trail
Ted Agres | Jun 24, 2001 | 4 min read
Apoptosis, a key process in the development of embryonic tissue differentiation, later helps to regulate the normal cellular life cycle by destroying damaged cells. When something goes awry, too little apoptosis can make cancer cells resistant to chemotherapy and even death-defiant. At the other extreme, premature or excessive apoptosis has been linked to neurodegenerative diseases, such as Alzheimer's, and to nerve cell loss in strokes. Not surprisingly, many major pharmaceutical companies rec
Mapping Subtelomeres
Ricki Lewis | Oct 14, 2001 | 4 min read
In genetics, certain terms sometimes mask what scientists do not yet understand, such as "junk DNA." Similarly, the chromosomal regions just proximal to the tips--the subtelomeres--have been dubbed "buffers," ill-defined DNA sequences that somehow support the telomeres, which control the cell cycle and cellular aging. A team of researchers from the Wistar Institute in Philadelphia, the University of California, Irvine, and John Radcliffe Hospital in Oxford, UK, has used single-copy sequences in
Ribozymes: Hearkening Back to an RNA World
Jeffrey Perkel | Sep 15, 2002 | 9 min read
Illustration: Ned Shaw LIKE MOLECULAR TOY-MAKERS, ribozyme researchers create tools with evolutionary, diagnostic, and therapeutic applications. Nearly 20 years ago, Tom Cech and Sidney Altman discovered that some naturally occurring RNAs could perform enzymatic reactions, earning these researchers the 1989 Nobel Prize in chemistry. Scientists have now identified several examples of RNA enzymes, or ribozymes. Most make or break the phosphodiester bonds in nucleic acid backbones, but some

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