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tag x ray crystallography neuroscience cell molecular biology

Accelerating X-ray Crystallography
Kelli Miller | Jan 12, 2003 | 8 min read
Courtesy of Astex Technology For years, the process of X-ray crystallography has moved at a tortoise's pace. "When I started in the field, it would typically take 20 person-years to produce a complete atomic model of one single protein. It was like a traffic jam in New York City. Every single part of the process was slow," says Stephen Burley, chief scientific officer and senior vice president of research at San Diego-based Structural GenomiX. The biggest holdup: obtaining a suitable crystal.
Microscopic image of a live amoeba.
Illuminating Specimens Through Live Cell Imaging
Charlene Lancaster, PhD | Mar 14, 2024 | 8 min read
Live cell imaging is a powerful microscopy technique employed by scientists to monitor molecular processes and cellular behavior in real time.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
X-ray Vision in Structural Genomics
Gregory Smutzer | Jun 10, 2001 | 10 min read
Updated! Suppliers of Tools for X-ray Crystallography Courtesy of Amersham Pharmacia BiotechDetail of the electron density map of deacetoxycephalosporin C synthase from Streptomyces clavuligerus. Two important approaches can be used to determine the three-dimensional structure of macromolecules. Nuclear magnetic resonance (NMR) spectroscopy yields information on the structure of proteins in solution, but it has a size limitation of approximately 150 amino acid residues (about 16,500 daltons),
Brighter, Smaller, Faster
Jeffrey M. Perkel | Feb 1, 2013 | 7 min read
As X-ray crystallography enters its second century, shrinking crystals and brighter light sources are redefining structural biology.
Proteomics Factories
Eugene Russo | Feb 6, 2000 | 9 min read
Figure: Gaetano Montelione and Yuanpeng Huang of Rutgers UniversityX-ray crystal structure of human basic fibroblast growth factor. With a bit of luck and sometimes decades of dedication, scientists have in recent years revealed fascinating vistas of biological structures at the atomic level using X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy. In 1997, Timothy Richmond, a professor of X-ray crystallography at the Swiss Federal Institute of Technology in Zurich, complete
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
Molecular Modeling Software Manufacturers Improve Functionality
Holly Ahern | Mar 19, 1995 | 8 min read
Imagine this scenario. You sit at your computer to study the structure of a crucial protein--one that you've painstakingly cloned, produced in a protein-expression system, and purified after many hours in the laboratory. The crystallography laboratory that you collaborate with produced crystals of your protein weeks ago. They collected X-ray diffraction data and plugged it into their workstation-based molecular-modeling system, coming up with a three-dimensional structure of your protein showin
Scorpion tags tumors
Amy Coombs | Oct 1, 2007 | 3 min read
Fluorescence indicates chlorotoxin binding to medulloblastoma cells in a mouse (right). Credit: Image by Mandana Veiseh, courtesy of AACR" />Fluorescence indicates chlorotoxin binding to medulloblastoma cells in a mouse (right). Credit: Image by Mandana Veiseh, courtesy of AACR Within minutes after being stung by the scorpion known as the deathstalker (Leiurus quinquestriatus), weakness starts to kick in. The feeling quickly spreads, paralyzing its prey (typically insects) for hours -
Molecular Blueprints
Cristina Luiggi | Mar 27, 2012 | 3 min read
Check out the latest crop of high-resolution structures and how they inform biological function.

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