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tag x ray crystallography neuroscience

Accelerating X-ray Crystallography
Kelli Miller | Jan 12, 2003 | 8 min read
Courtesy of Astex Technology For years, the process of X-ray crystallography has moved at a tortoise's pace. "When I started in the field, it would typically take 20 person-years to produce a complete atomic model of one single protein. It was like a traffic jam in New York City. Every single part of the process was slow," says Stephen Burley, chief scientific officer and senior vice president of research at San Diego-based Structural GenomiX. The biggest holdup: obtaining a suitable crystal.
X-ray Vision in Structural Genomics
Gregory Smutzer | Jun 10, 2001 | 10 min read
Updated! Suppliers of Tools for X-ray Crystallography Courtesy of Amersham Pharmacia BiotechDetail of the electron density map of deacetoxycephalosporin C synthase from Streptomyces clavuligerus. Two important approaches can be used to determine the three-dimensional structure of macromolecules. Nuclear magnetic resonance (NMR) spectroscopy yields information on the structure of proteins in solution, but it has a size limitation of approximately 150 amino acid residues (about 16,500 daltons),
Proteomics Factories
Eugene Russo | Feb 6, 2000 | 9 min read
Figure: Gaetano Montelione and Yuanpeng Huang of Rutgers UniversityX-ray crystal structure of human basic fibroblast growth factor. With a bit of luck and sometimes decades of dedication, scientists have in recent years revealed fascinating vistas of biological structures at the atomic level using X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy. In 1997, Timothy Richmond, a professor of X-ray crystallography at the Swiss Federal Institute of Technology in Zurich, complete
Where Proteins Meet
Aparna Sreenivasan | Aug 24, 2003 | 3 min read
Courtesy of Pierce Biotechnology Pierce Biotechnology has expanded its repertoire of protein chemistry products with the new ProFound Protein Interaction Mapping Kit, which helps researchers to pinpoint where protein partners come together. The technique takes advantage of a unique cleaving agent and bypasses the need for more complex approaches such as nuclear magnetic resonance or X-ray crystallography, says Patti Domen, a senior research scientist who designed and tested the product at Pie
Molecular Modeling Software Manufacturers Improve Functionality
Holly Ahern | Mar 19, 1995 | 8 min read
Imagine this scenario. You sit at your computer to study the structure of a crucial protein--one that you've painstakingly cloned, produced in a protein-expression system, and purified after many hours in the laboratory. The crystallography laboratory that you collaborate with produced crystals of your protein weeks ago. They collected X-ray diffraction data and plugged it into their workstation-based molecular-modeling system, coming up with a three-dimensional structure of your protein showin
Those We Lost in 2019
Ashley Yeager | Dec 30, 2019 | 6 min read
The scientific community said goodbye to Sydney Brenner, Paul Greengard, Patricia Bath, and a number of other leading researchers this year.
Legacies Left Behind in 2015
Karen Zusi | Dec 30, 2015 | 5 min read
A look at the contributions of some of the prominent researchers who died this year
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Those We Lost in 2018
Ashley Yeager | Dec 26, 2018 | 10+ min read
The scientific community said goodbye to a number of leading researchers this year.
The 1999 Lasker Awards
Eugene Russo | Oct 24, 1999 | 8 min read
Editor's Note: This year's winners of the Albert Lasker Medical Research Awards were honored for their achievements at an Oct. 1 luncheon at the Hotel Pierre in New York. Three researchers were recognized for their work on ion channels, two for their development of a novel hypertension medication, and one for a lifetime of contributions to neuroscience. Following are three stories on the winners. More information is available on the Web at www.laskerfoundation.org. Basic Award Recognizes Ion Ch

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