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tag x ray crystallography developmental biology evolution

Accelerating X-ray Crystallography
Kelli Miller | Jan 12, 2003 | 8 min read
Courtesy of Astex Technology For years, the process of X-ray crystallography has moved at a tortoise's pace. "When I started in the field, it would typically take 20 person-years to produce a complete atomic model of one single protein. It was like a traffic jam in New York City. Every single part of the process was slow," says Stephen Burley, chief scientific officer and senior vice president of research at San Diego-based Structural GenomiX. The biggest holdup: obtaining a suitable crystal.
X-ray Vision in Structural Genomics
Gregory Smutzer | Jun 10, 2001 | 10 min read
Updated! Suppliers of Tools for X-ray Crystallography Courtesy of Amersham Pharmacia BiotechDetail of the electron density map of deacetoxycephalosporin C synthase from Streptomyces clavuligerus. Two important approaches can be used to determine the three-dimensional structure of macromolecules. Nuclear magnetic resonance (NMR) spectroscopy yields information on the structure of proteins in solution, but it has a size limitation of approximately 150 amino acid residues (about 16,500 daltons),
Proteomics Factories
Eugene Russo | Feb 6, 2000 | 9 min read
Figure: Gaetano Montelione and Yuanpeng Huang of Rutgers UniversityX-ray crystal structure of human basic fibroblast growth factor. With a bit of luck and sometimes decades of dedication, scientists have in recent years revealed fascinating vistas of biological structures at the atomic level using X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy. In 1997, Timothy Richmond, a professor of X-ray crystallography at the Swiss Federal Institute of Technology in Zurich, complete
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
Notable
Jeffrey Perkel | Apr 14, 2002 | 4 min read
K. Rein et al., "The Drosophila standard brain," Current Biology, 12[3]:227-31, Feb. 5, 2002. "The authors present an approach to create a 3D image of the fly brain. This is a very useful resource tool that will make it possible to create an atlas of gene expression patterns and will be very useful for analyzing brain structure in mutant backgrounds." —Oliver Hobert, Columbia University College of Physicians and Surgeons, US X-Ray Crystallography F.J. Lopez-Jaramillo et al., "Crystalliz
Molecular Structures Provide Insights Into Larger Questions In Biology
Neeraja Sankaran | Sep 4, 1994 | 6 min read
Editor's Note: This is the second part of a two-part series on the field of structural biology. Part 1, presented in the Aug. 22, 1994, issue of The Scientist (page 14), discussed the evolution of this booming discipline. This article focuses on structural biology's key areas of basic and applied research and looks ahead to its future. Following are some of the professional organizations whose memberships include structural biolo
Molecular Structures Provide Insights Into Larger Questions In Biology
Neeraja Sankaran | Sep 4, 1994 | 6 min read
Editor's Note: This is the second part of a two-part series on the field of structural biology. Part 1, presented in the Aug. 22, 1994, issue of The Scientist (page 14), discussed the evolution of this booming discipline. This article focuses on structural biology's key areas of basic and applied research and looks ahead to its future. Following are some of the professional organizations whose memberships include structural biolo
Molecular Modeling Software Manufacturers Improve Functionality
Holly Ahern | Mar 19, 1995 | 8 min read
Imagine this scenario. You sit at your computer to study the structure of a crucial protein--one that you've painstakingly cloned, produced in a protein-expression system, and purified after many hours in the laboratory. The crystallography laboratory that you collaborate with produced crystals of your protein weeks ago. They collected X-ray diffraction data and plugged it into their workstation-based molecular-modeling system, coming up with a three-dimensional structure of your protein showin
Unnatural Base Pair Replication
Sabrina Richards | Jun 6, 2012 | 3 min read
New crystallography images show that artificial DNA bases take on a surprisingly normal geometry when bound by polymerase.
Sensory Biology Around the Animal Kingdom
The Scientist | Sep 1, 2016 | 10+ min read
From detecting gravity and the Earth’s magnetic field to feeling heat and the movement of water around them, animals can do more than just see, smell, touch, taste, and hear.

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