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tag x ray crystallography disease medicine developmental biology

Accelerating X-ray Crystallography
Kelli Miller | Jan 12, 2003 | 8 min read
Courtesy of Astex Technology For years, the process of X-ray crystallography has moved at a tortoise's pace. "When I started in the field, it would typically take 20 person-years to produce a complete atomic model of one single protein. It was like a traffic jam in New York City. Every single part of the process was slow," says Stephen Burley, chief scientific officer and senior vice president of research at San Diego-based Structural GenomiX. The biggest holdup: obtaining a suitable crystal.
X-ray Vision in Structural Genomics
Gregory Smutzer | Jun 10, 2001 | 10 min read
Updated! Suppliers of Tools for X-ray Crystallography Courtesy of Amersham Pharmacia BiotechDetail of the electron density map of deacetoxycephalosporin C synthase from Streptomyces clavuligerus. Two important approaches can be used to determine the three-dimensional structure of macromolecules. Nuclear magnetic resonance (NMR) spectroscopy yields information on the structure of proteins in solution, but it has a size limitation of approximately 150 amino acid residues (about 16,500 daltons),
Proteomics Factories
Eugene Russo | Feb 6, 2000 | 9 min read
Figure: Gaetano Montelione and Yuanpeng Huang of Rutgers UniversityX-ray crystal structure of human basic fibroblast growth factor. With a bit of luck and sometimes decades of dedication, scientists have in recent years revealed fascinating vistas of biological structures at the atomic level using X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy. In 1997, Timothy Richmond, a professor of X-ray crystallography at the Swiss Federal Institute of Technology in Zurich, complete
Yale Researcher To Receive Once-In-A-Century Prize
Neeraja Sankaran | Oct 29, 1995 | 2 min read
On November 8, the University of Würzburg, Germany, is hosting a ceremony to celebrate the 100th anniversary of the discovery of X-rays by its Nobel-winning alumnus, Wilhelm Conrad Röntgen. To mark this event, the university is awarding three prizes-in the categories of biosciences, medicine, and physics-to outstanding researchers who have worked with X-rays in these fields. The awards will not be given again for 100 years. X-RAY VISIONARY: Axel Brünger studes the structure of
Notable
Jeffrey Perkel | Apr 14, 2002 | 4 min read
K. Rein et al., "The Drosophila standard brain," Current Biology, 12[3]:227-31, Feb. 5, 2002. "The authors present an approach to create a 3D image of the fly brain. This is a very useful resource tool that will make it possible to create an atlas of gene expression patterns and will be very useful for analyzing brain structure in mutant backgrounds." —Oliver Hobert, Columbia University College of Physicians and Surgeons, US X-Ray Crystallography F.J. Lopez-Jaramillo et al., "Crystalliz
Molecular Modeling Software Manufacturers Improve Functionality
Holly Ahern | Mar 19, 1995 | 8 min read
Imagine this scenario. You sit at your computer to study the structure of a crucial protein--one that you've painstakingly cloned, produced in a protein-expression system, and purified after many hours in the laboratory. The crystallography laboratory that you collaborate with produced crystals of your protein weeks ago. They collected X-ray diffraction data and plugged it into their workstation-based molecular-modeling system, coming up with a three-dimensional structure of your protein showin
Defining Rare Disorders: A Profile of Judith Hall
Anna Azvolinsky | Sep 1, 2019 | 8 min read
By bringing genetics into clinical medicine, the University of British Columbia medical geneticist helped to identify the gene mutations responsible for many rare diseases.
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
New Immunoassay Products Let Users Put New Twists On Old Themes
Lisa Seachrist | Sep 29, 1996 | 8 min read
Advanced Chemtech AFfinity Bioreagents Biodesign International Bio-Rad Laboratories BioSource International Boehringer Mannheim Biochemicals Cardinal Associates Inc. Immunochemistry Technologies Peninsula Laboratories Inc. Tropix Inc. Wako Chemicals USA Inc. Wallac Inc. A quick inventory of nearly any molecular biology laboratory these days will turn up a kudzu-like infestation of monoclonal antibodies, fluorescent-tagged secondary antibodies, and immunoassay kits. Immunoassays have become de

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