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tag x ray crystallography genetics genomics

Accelerating X-ray Crystallography
Kelli Miller | Jan 12, 2003 | 8 min read
Courtesy of Astex Technology For years, the process of X-ray crystallography has moved at a tortoise's pace. "When I started in the field, it would typically take 20 person-years to produce a complete atomic model of one single protein. It was like a traffic jam in New York City. Every single part of the process was slow," says Stephen Burley, chief scientific officer and senior vice president of research at San Diego-based Structural GenomiX. The biggest holdup: obtaining a suitable crystal.
X-ray Vision in Structural Genomics
Gregory Smutzer | Jun 10, 2001 | 10 min read
Updated! Suppliers of Tools for X-ray Crystallography Courtesy of Amersham Pharmacia BiotechDetail of the electron density map of deacetoxycephalosporin C synthase from Streptomyces clavuligerus. Two important approaches can be used to determine the three-dimensional structure of macromolecules. Nuclear magnetic resonance (NMR) spectroscopy yields information on the structure of proteins in solution, but it has a size limitation of approximately 150 amino acid residues (about 16,500 daltons),
Proteomics Factories
Eugene Russo | Feb 6, 2000 | 9 min read
Figure: Gaetano Montelione and Yuanpeng Huang of Rutgers UniversityX-ray crystal structure of human basic fibroblast growth factor. With a bit of luck and sometimes decades of dedication, scientists have in recent years revealed fascinating vistas of biological structures at the atomic level using X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy. In 1997, Timothy Richmond, a professor of X-ray crystallography at the Swiss Federal Institute of Technology in Zurich, complete
Genome Guru
Karen Hopkin | Oct 1, 2009 | 7 min read
By Karen Hopkin Genome Guru With some creative coding, Tim Hubbard has helped scientists see into the future of biomedicine. © Cate Gillon Tim Hubbard claims he knows nothing about genetics. But he was drawn into the high-stakes world of genomics by a job offer he couldn’t refuse. Hubbard had been working on algorithms for predicting protein structures at the MRC Centre for Protein Engineering in the Un
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Genome Database Booms As Journals Take The Hard Line
Christopher Anderson | Oct 29, 1989 | 5 min read
For researchers in such fast-growing fields as gene sequencing and crystallography, the end of traditional scientific publications may be in sight. Quietly, over the last year, a trial program in the electronic submission of data has laid the foundations for a revolution that may someday replace the research journal as the vehicle for scientific communication. In an agreement With GenBank, the main U.S. gene sequence database, nearly a dozen journals are refusing to accept papers with sequ
Bioinformatics, Genomics, and Proteomics
Christopher Smith | Nov 26, 2000 | 10+ min read
Data Mining Software for Genomics, Proteomics and Expression Data (Part 1) Data Mining Software for Genomics, Proteomics and Expression Data (Part 2) High-throughput (HT) sequencing, microarray screening and protein expression profiling technologies drive discovery efforts in today's genomics and proteomics laboratories. These tools allow researchers to generate massive amounts of data, at a rate orders of magnitude greater than scientists ever anticipated. Initiatives to sequence entire genom
Crystal Illumination
Laura Lane | Jan 18, 2004 | 8 min read
Researchers use automation to boost crystallography efforts, resulting in more data in less time, from less protein
Europe boosts post genomic research
Helen Gavaghan(gavers@supanet.com) | Mar 25, 2002 | 4 min read
25 million to three pan European post genomic projects signals a shift in EU funding of science.
Benefiting from the Human Genome
Jennifer Fisher Wilson | Apr 29, 2001 | 5 min read
As one of the leading causes of death in the United States, cancer continues to challenge those working in the field. Despite long-ongoing research, much work remains before cancer is eradicated. Really a large family of diseases, cancer requires diverse methods for treatment and diagnosis that will only come with a better knowledge of the basic biology of the affected systems. Advances in understanding the causes, new techniques for drug discovery, and increased funding of cancer research have

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