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image: Lost in Space

Lost in Space

By | September 1, 2011

Looking for a more realistic way to study memory, we turned to place cells­­—­a network of cells that record a rat’s memory of an environment. 

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image: Molecular Learning

Molecular Learning

By | September 1, 2011

Long-term potentiation (LTP), discovered in the 1970s, was later shown to be the molecular basis of memory. 

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image: The Seat of Memory

The Seat of Memory

By | September 1, 2011

Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to the aging process.

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image: The Cytokine Cycle

The Cytokine Cycle

By | September 1, 2011

The initiating cause of Alzheimer’s disease is still unknown. However, from our studies it’s clear that many types of neuronal damage—­­from traumatic brain injury, to epilepsy, infection, or genetic predisposition—­can activate brain immune cells—microglia and astrocytes-- promoting them to produce IL-1 and S100 inflammatory cytokines.

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image: Velcro Helps Muscles Grow

Velcro Helps Muscles Grow

By | August 31, 2011

Stretching muscle cells as they grow helps promote the expression of growth factors.

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image: Next Generation: Hundreds of Cell-Analyses at Once

Next Generation: Hundreds of Cell-Analyses at Once

By | August 11, 2011

A new microfluidics chip lets researchers analyze the nucleic acids of 300 individual cells simultaneously.

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image: Lab-Grown Sperm

Lab-Grown Sperm

By | August 4, 2011

Healthy mice are born from germ cell precursors grown in vitro.

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image: Nicotine Protects Against Parkinson’s?

Nicotine Protects Against Parkinson’s?

By | August 3, 2011

The addictive component of cigarettes saves dopamine neurons from a Parkinson's-like decline, providing a new avenue for potential treatment.

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image: Deconstructing the Mosaic Brain

Deconstructing the Mosaic Brain

By | August 1, 2011

Sequencing the DNA of individual neurons is a way to dissect the genes underlying major neurological and psychological disorders.

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image: Chimp Brains Don’t Shrink with Age

Chimp Brains Don’t Shrink with Age

By | July 25, 2011

Unlike human brains, chimpanzee brains don’t get smaller as they age, suggesting that pronounced neurological decline is a uniquely human byproduct of our oversized brains and extreme longevity.

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