Deterioration of long-lived proteins on the surface of neuronal nuclei in the brain could lead to age-related defects in nervous function.
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This year’s winners research topics ranging from stem cell regulation to brain damage from football injuries.
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Researchers and pharma companies have tried to attack this disease by reducing amyloid plaques, but inflammation may be the real culprit.
Looking for a more realistic way to study memory, we turned to place cells—a network of cells that record a rat’s memory of an environment. Each place cell would fire only when the rat was in one particular location in space, creating a map as the
Long-term potentiation (LTP), discovered in the 1970s, was later shown to be the molecular basis of memory. Since many diseases of aging affect memory, could memory formation and storage be altered by the same mechanisms in normal aging and diseased
Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to t
The initiating cause of Alzheimer’s disease is still unknown. However, from our studies it’s clear that many types of neuronal damage—from traumatic brain injury, to epilepsy, infection, or genetic predisposition—can activate brain immune cells—
The addictive component of cigarettes saves dopamine neurons from a Parkinson's-like decline, providing a new avenue for potential treatment.
Unlike human brains, chimpanzee brains don’t get smaller as they age, suggesting that pronounced neurological decline is a uniquely human byproduct of our oversized brains and extreme longevity.
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