Karen Young Kreeger | Feb 18, 1996 | 2 min read
Comments by Virginia M.-Y. Lee and John Q. Trojanowski, University of Pennsylvania School of Medicine New Twist On Tangles: Research conducted by Penn's John Trojanowski and Virginia Lee suggests that phosphatases may be "lazy," or inactive, in Alzheimer's tangles. This paper offers a new way of looking at the formation of tangles-a twisted neuronal knot of paired helical filaments (PHFs). PHFs are one of the two primary diagnostic features found in the brains of Alzheimer's disease (AD) pat