Rudolf Jaenisch enjoys climbing mountains, rafting rapids, and unraveling the secrets of pluripotency—knowledge that could someday lead to personalized regenerative medicine.
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There are many ways that epigenetic effects regulate the activation or repression of genes. Here are a few molecular tricks cells use to read off the right genetic program.
Epigenetic events regulate the activities of genes without changing the DNA sequence. Different genes are expressed depending on the methyl-marks attached to DNA itself and by changes in the structure and/or composition of chromatin. The main compone
A snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000
A father’s determination to help his son resulted in an experimental treatment for autism that uses roundworms to modulate inflammatory immune responses. Can the worms be used to treat other diseases?
Meet the people behind studies that use nematodes to treat inflammatory diseases.
Gabriele Sorci discusses how invaders can band together to more effectively infect hosts.
As much as rainforests or deep-sea vents, the human gut holds rich stores of microbial chemicals that should be mined for their pharmacological potential.
Microbes, both good and bad, can exert direct effects on host cells and vice versa. For example, pathogenic bacteria such as some strains of E. coli and Salmonella reduce the overall number of normal gut commensal bacteria, promoting their own growth
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