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tag drug metabolizing enzymes disease medicine

FDA Approves Oral Drug for Fabry Disease
Ashley Yeager | Aug 13, 2018 | 2 min read
The medicine increases the activity of a deficient enzyme in certain patients with the condition.
Lasker Award winner Piet Borst sits at his desk.
A Journey With Metabolism, Parasites, and Cancer
Laura Tran, PhD | Sep 21, 2023 | 7 min read
Piet Borst led stellar work on cell organelles, trypanosomes, and cancer drug resistance during the golden age of biology.
ribbon model of phenylalanine hydroxylase enzyme
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Abby Olena, PhD | Aug 6, 2021 | 4 min read
A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.
illustration of liver with veins in blue and arteries in red.
Ethanol-Making Microbe Tied to Nonalcoholic Fatty Liver Disease
Natalia Mesa, PhD | Oct 19, 2022 | 4 min read
A study adds to evidence linking gut bacteria to liver conditions in people who don’t drink excessive amounts of alcohol. 
Protein Synthesis Enzymes Have Evolved Additional Jobs
Amber Dance | Jun 1, 2020 | 10+ min read
Aminoacyl-tRNA synthetases, which help translate the genetic code into protein, also function in angiogenesis, fat metabolism, and more.
Emily Scott: Enzyme Explorer
Dan Cossins | Mar 1, 2013 | 3 min read
Associate Professor, Medicinal Chemistry, University of Kansas. Age: 43
The Inequality of Drug Metabolism
Karen Young Kreeger | Mar 17, 2002 | 6 min read
Editor's Note: This is the fifth article in a series on sex-based differences in the biology of males and females. The final article in the series will cover sex-based differences in life expectancy. Lisa Damiani More than 30 years ago, researchers noted for the first time the pharmacokinetic differences between men and women. They found that women pass antipyrine, a drug used to study liver metabolism, more quickly than men; this occurred around ovulation and during the luteal phase of their m
Discovered: Metabolic Mechanism of Cytokine Storms
Ruth Williams | Apr 15, 2020 | 3 min read
By studying influenza in mice and cells, researchers identify a glucose metabolism pathway critical to the dysregulated immune response that kills many infectious disease patients, including those with COVID-19.
Making Medicine Personal
Aileen Constans | Sep 29, 2002 | 8 min read
Image: Erica P. Johnson "Never share your prescription." That's good advice: People may react differently to drugs, whether because of weight, gender, or metabolic differences. When a physician writes a prescription, one would think that it is custom-made for the patient. But, more often than not, it's "Take two and call me in the morning." Advocates of pharmacogenomics say a better approach would be to custom-design medications to fit each patient's needs; some scientists argue, however, that

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