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bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Bacteria and Humans Have Been Swapping DNA for Millennia
Kelly Robinson and Julie Dunning Hotopp | Oct 1, 2016 | 8 min read
Bacteria inhabit most tissues in the human body, and genes from some of these microbes have made their way to the human genome. Could this genetic transfer contribute to diseases such as cancer?
A fruit bat in the hands of a researcher
How an Early Warning Radar Could Prevent Future Pandemics
Amos Zeeberg, Undark | Feb 27, 2023 | 8 min read
Metagenomic sequencing can help detect unknown pathogens, but its widespread use faces challenges.
Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Notebook
The Scientist Staff | Mar 29, 1998 | 8 min read
Contents Moral Might Self-Validation More Alzheimer's Progress Broader Role For Mobile DNA Preferential Hearing Special Delivery Perfect Pitch Genes Imaging Dsylexia Date: March 30, 1998 A GUIDE TO ETHICS: Eric Meslin took over leadership of the National Bioethics Advisory Commission last month. MORAL MIGHT Eric M. Meslin, 36, has taken over leadership of the National Bioethics Advisory Commission (NBAC) in Rockville, Md. Harold T. Shapiro, NBAC's chairman and president of Princeton Univers
Hands-On Power
Mike May | Nov 16, 2003 | 6 min read
Courtesy of Mike Curtis  TAG, YOU'RE SICK! School children learn about communicable diseases with handheld computers and a program called Cooties. In the 1830s, Charles Darwin used a pen and paper to document finches and other fauna and flora in the Galápagos Islands. For the next century and a half, most scientists relied on the same tools to take notes or collect data. Today, Dave Anderson, associate professor of biology at Wake Forest University, follows in Darwin's footsteps--
Genetic Parasites and a Whole Lot More
Barry Palevitz | Oct 15, 2000 | 10+ min read
Photo: Ori Fragman, Hebrew University Hordeum spontaneum, the plant studied for BARE-1 retroelements. With genome sequences arriving almost as regularly as the morning paper, the public's attention is focused on genes--new genes to protect crops against pests; rogue genes that make bacteria resistant to antibiotics; faulty genes that, if fixed, could cure diseases such as muscular dystrophy. What many people don't realize is that genes account for only part of an organism's DNA, and in many c
TIGR Introduces Vibrio cholerae Genome
Ricki Lewis | Aug 20, 2000 | 6 min read
The bacterium that causes cholera has joined the elite club of organisms whose genomes have been sequenced. Since 1817, seven pandemics of cholera have left millions dead from the dehydration caused by relentless diarrhea. But the disease has been noted for at least 1,000 years. "Cholera is one of the most ancient diseases we know about. Its home is the Ganges delta in India and Bangladesh; it has a long history there. It became a worldwide disease in 1817, when the first pandemic started

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