A whole-body immunostaining method allowed researchers to achieve cellular resolution at the whole-organism level.

CITE-seq draws upon the unbiased nature of single-cell RNA sequencing to gather new insights about protein and gene expression within the same cell.

Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy.

The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.

Maternal infection during pregnancy may be associated with autism, as previous studies have suggested—but perhaps not in a causal way.

Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.

Gaining a better understanding of the dynamic and reciprocal interactions between cancer cells and the tumor microenvironment is essential for improving patient diagnosis and treatment.

Organelles isolated from two types of neurons and a nonneuronal astrocyte in the mouse cerebellum showed varying levels of proteins, hinting at functional differences.

Conversations between the immune and central nervous systems are proving to be essential for the healthy social behavior, learning, and memory.

From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.