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tag worm genetics genomics

Long live the worm!
Jeff Perkel | Jun 29, 2005 | 1 min read
In tomorrow's (July 1) issue of Genes & Development, Siu Sylvia Lee, of the department of molecular biology and genetics at Cornell University in Ithaca, NY, and Gary Ruvkun, of the department of genetics at Harvard Medical School, report ?the first genome-wide functional genomic screen for longevity genes.? The two teams used a library of 16,475 RNA interference constructs (created by Julie Ahringer at the University of Cambridge, UK) to inactivate genes in the nematode, Caenorhabditis eleg
Designing Worm Proteins
Jef Akst | Aug 15, 2011 | 1 min read
For the first time, researchers have engineered a multicellular organism that incorporates a synthetic amino acid into its proteins.
Model worm susceptible to virus
Carrie Arnold | Jan 24, 2011 | 3 min read
Researchers discover the first virus that can infect Caenorhabditis elegans
Genome Economy
Ricki Lewis | Jun 10, 2001 | 10 min read
The Human Genome Project's discovery1 that the human body runs on an instruction manual of a mere 35,000 or so genes--compared to the worm's 19,000, the fruit fly's 13,000, and the tiny mustard relative Arabidopsis thaliana's 25,000--placed humanity on an even playing field with these other, supposedly simpler, organisms. It was a humbling experience, but humility quickly gave way to awe with the realization that the human genome might encode 100,000 to 200,000 proteins. Scientists base this num
Pufferfish Genomes Probe Human Genes
Ricki Lewis | Mar 17, 2002 | 7 min read
It may be humbling to think that humans have much in common with pufferfish, but at the genome level, the two are practically kissing cousins. "In terms of gene complement, we are at least 90% similar—probably higher. There are big differences in gene expression levels and alternate transcripts, but if you're talking about diversity, number and types of proteins, then it's pretty difficult to tell us apart," says Greg Elgar, group leader of the Fugu genome project at the Medical Research C
Epigenetics: Genome, Meet Your Environment
Leslie Pray | Jul 4, 2004 | 10+ min read
©Mehau Kulyk/Photo Researchers, IncToward the end of World War II, a German-imposed food embargo in western Holland – a densely populated area already suffering from scarce food supplies, ruined agricultural lands, and the onset of an unusually harsh winter – led to the death by starvation of some 30,000 people. Detailed birth records collected during that so-called Dutch Hunger Winter have provided scientists with useful data for analyzing the long-term health effects of prenat
Preimplantation Genetic Diagnosis: The Next Big Thing?
Ricki Lewis | Nov 12, 2000 | 9 min read
Courtesy of David Hill, ART Reproductive Center Inc.Two separated blastomeres subjected to FISH analysis to check the chromosomes. In early October, preimplantation genetic diagnosis (PGD) made headlines when a Colorado couple used assisted reproductive technology (ART) to have a baby named Adam, whose umbilical cord stem cells could cure his six-year-old sister Molly's Fanconi anemia.1 When Adam Nash was a ball of blastomere cells, researchers at the Reproductive Genetics Institute at Illinois
Trickle-Down Genomics: Reforming ""Small Science"" As We Know It
Edward Smith | Jul 18, 1999 | 7 min read
if (n == null) The Scientist - Trickle-Down Genomics: Reforming ""Small Science"" As We Know It The Scientist 13[15]:19, Jul. 19, 1999 Opinion Trickle-Down Genomics: Reforming "Small Science" As We Know It By Edward J. Smith Each generation attempts to develop programs and activities that help it fulfill the ancient Chinese wish "May you live in interesting times." These are indeed interesting times from the perspective of the biologist: The complete geno
Q&A, Genetics & Genomics, research bias, COVID-19, SARS-CoV-2, pandemic, coronavirus, big data
COVID-19 Research Biased Toward Only a Handful of Genes
Amanda Heidt | Nov 24, 2020 | 5 min read
Thomas Stoeger of Northwestern University has previously studied scientists’ limited focus on certain genes. In a new study, he shows how these same behaviors extend into the science of COVID-19.
Is This Life?
Jack Lucentini | Jan 1, 2006 | 8 min read
FEATUREIs This Life? BY JACK LUCENTINI Hordes of green, sub-microscopic balloons float in a watery mixture in Jack Szostak's laboratory at Harvard Medical School. They come in a variety of shapes: spheres, blimps, worms. And as Szostak examines magnified images of them, he can't help but notice a striking resemblance to bacterial ecosystems, puls

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