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tag prey genetics genomics

Finding a Mate
Barbara Cunningham | Apr 1, 2001 | 9 min read
Available Two-hybrid Systems Graphic: Leza BerardoneGenome sequencing has produced a vast supply of proteins in need of a functional identity. One way to identify a protein's function is to identify its interacting partners, because proteins often work in pairs or as part of large complexes. Scientists traditionally have used biophysical or biochemical methods (such as affinity chromatography or co-immunoprecipitation) to study protein-protein interactions. More recently, two-hybrid and phage-d
Probing Protein Interactions
Laura Defrancesco | Apr 14, 2002 | 8 min read
The challenge of proteomics is personified in the Greek god, Proteus. The keeper of all knowledge, past, present and future, Proteus would not give up any information easily; even while held down, he would struggle and assume different forms before giving anything up. Remarkably, proteomics, and proteins for that matter, were not named after Proteus, but the imagery could not be more fitting. It's still anyone's guess what the final gene count will be in the human genome, let alone the total nu
Software Solutions to Proteomics Problems
Bob Sinclair | Oct 14, 2001 | 10 min read
As genome sequencing becomes a regular occurrence, biology's attention can turn to the next logical step: proteomics. Fundamentally, proteomics is nothing less than the complete catalog of every protein in a given tissue, organ, or organism under a defined growth or disease state. Sometimes this definition is expanded to include protein-protein interactions. The data describe the types and quantities of proteins present and also indicate other proteins with which these molecules are complexed.
Lab Tools: Close Encounters
Jeffrey M. Perkel | Oct 1, 2008 | 7 min read
Protein-protein interaction assays for all occasions.
Antibody Alternatives
Paul Ko Ferrigno and Jane McLeod | Feb 1, 2016 | 10+ min read
Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.
Steal My Sunshine
David Smith | Jan 1, 2013 | 10+ min read
How photosynthetic organisms get taken up, passed around, and discarded throughout the eukaryotic domain
The Yeast Two-hybrid Assay
Mark Greener(mgreener@the-scientist.com) | Aug 28, 2005 | 8 min read
No protein is an island.
Who Sleeps?
The Scientist and Jerome Siegel | Mar 1, 2016 | 10+ min read
Once believed to be unique to birds and mammals, sleep is found across the metazoan kingdom. Some animals, it seems, can’t live without it, though no one knows exactly why.
Brains in Action
The Scientist | Feb 1, 2014 | 10+ min read
Neuroscientists are automating neural imaging and recording, allowing them to monitor increasingly large swaths of the brain in living, behaving animals.
 
An Ocean of Viruses
Joshua S. Weitz and Steven W. Wilhelm | Jul 1, 2013 | 10+ min read
Viruses abound in the world’s oceans, yet researchers are only beginning to understand how they affect life and chemistry from the water’s surface to the sea floor.

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