As X-ray crystallography enters its second century, shrinking crystals and brighter light sources are redefining structural biology.
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A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. In order to replicate the structure of an enzyme’s transition state, whic
Targeting the briefest moment in chemistry may lead to an exceptionally strong new class of drugs.
Knocking electrons out of atomic orbit with a laser allows researchers to take femtosecond-scale “movies” of molecules in motion.
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